{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:45:05Z","timestamp":1789685105317,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T00:00:00Z","timestamp":1741392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Cross\u2010sectional imaging may be used to characterise the location and extent of colorectal mesenchymal tumours (CRMTs). Given the anticipated variation in tumour behaviour and varying morbidity based on surgical margins, a reliable, non\u2010invasive means of predicting malignant potential could facilitate case management. The purpose of this multi\u2010institutional, retrospective study was to determine the diagnostic accuracy of contrast\u2010enhanced CT for distinguishing benign and malignant CRMTs. Twenty\u2010seven dogs with CRMTs were included. Initial diagnoses were reviewed, and slides or blocks were available for 24\/27 dogs for further histologic review and immunohistochemical labelling for smooth muscle actin, KIT and vimentin. Two masked radiologists reviewed DICOM images for tumour characteristics, including a final, binary, consensus, subjective interpretation of malignancy. Eighteen tumours (66.7%) were classified as leiomyoma, one (3.7%) as a benign other non\u2010lymphogenic intestinal mesenchymal tumour (benign), one (3.7%) as leiomyosarcoma, and seven (25.9%) as gastrointestinal stromal tumour (malignant). Agreement between radiologists ranged from none to weak for categorical variables, with no agreement (<jats:italic>\u03ba<\/jats:italic>\u2009=\u20090.135) for the final assessment of a tumour as benign or malignant. Substantial overlap was noted between groups, with no single categorical variable demonstrating high accuracy as a predictor of malignancy. Consensus final assessment was a sensitive (80.0%) but not specific (29.4%) predictor of malignancy (accuracy: 48.2%). No association was identified between CT determination of malignancy and histologic determination of malignancy (<jats:italic>p<\/jats:italic>\u2009=\u20090.678). Non\u2010standardised contrast\u2010enhanced CT was ineffective at distinguishing malignant from benign CRMTs in this study.<\/jats:p>","DOI":"10.1111\/vco.13047","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:54:57Z","timestamp":1741740897000},"page":"216-223","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Contrast\u2010Enhanced Computed Tomography for Identification of Potential Malignancy in Canine Colorectal Mesenchymal Tumours"],"prefix":"10.1111","volume":"23","author":[{"given":"Alexandria D.","family":"Bourgeois","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine and Surgery University of Missouri College of Veterinary Medicine  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3765-429X","authenticated-orcid":false,"given":"Owen T.","family":"Skinner","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Surgery University of Missouri College of Veterinary Medicine  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J.","family":"Karnia","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Surgery University of Missouri College of Veterinary Medicine  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda C.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology University of Missouri College of Veterinary Medicine  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3022-8888","authenticated-orcid":false,"given":"Dae Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology University of Missouri College of Veterinary Medicine  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aitor","family":"Gallastegui","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine, University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen A.","family":"Griffin","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine School of Veterinary Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meaghan","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine and Biomedical Sciences, Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8458-1735","authenticated-orcid":false,"given":"Brandan G.","family":"Wustefeld\u2010Janssens","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine and Biomedical Sciences, Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8332-9706","authenticated-orcid":false,"given":"Gabrielle S.","family":"Fontes","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6695-6273","authenticated-orcid":false,"given":"Laura E.","family":"Selmic","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Traverson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine, North Carolina State University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos H.","family":"de M. Souza","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine, University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Bertran","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine, University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Thomsen","sequence":"additional","affiliation":[{"name":"VCA West Coast Specialty and Emergency Animal Hospital  Fountain Valley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arathi","family":"Vinayak","sequence":"additional","affiliation":[{"name":"VCA West Coast Specialty and Emergency Animal Hospital  Fountain Valley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan A.","family":"Mickelson","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Surgery University of Missouri College of Veterinary Medicine  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098587701400602"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2754\/avb201382040387"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.229.7.1130"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810380397"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.230.9.1329"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.40-1-42"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098589703400406"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985813478211"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1040638715578878"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-34-6-451"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani11051361"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2010.01748.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198011000-00013"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12650"},{"key":"e_1_2_8_16_1","first-page":"433","volume-title":"Tumors in Domestic Animals","author":"Cooper B. J.","year":"2017"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.11613\/BM.2012.031"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.13174"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2019.10.007"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20970"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2006.09.001"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2012.07.005"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23803"},{"key":"e_1_2_8_24_1","unstructured":"M.vonMehren J. M.Kane S. A.Armstrong et\u00a0al. \u201cNCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Gastrointestinal Stromal Tumors V.1.2024 \u201d(2024) www.nccn.org\/patients."},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2012.05.008"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol30010034"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-017-6087-9"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15335"}],"container-title":["Veterinary and Comparative Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.13047","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T10:22:38Z","timestamp":1747390958000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vco.13047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,8]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/vco.13047"],"URL":"https:\/\/doi.org\/10.1111\/vco.13047","archive":["Portico"],"relation":{},"ISSN":["1476-5810","1476-5829"],"issn-type":[{"value":"1476-5810","type":"print"},{"value":"1476-5829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,8]]},"assertion":[{"value":"2024-05-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}