{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:28:47Z","timestamp":1787840927491,"version":"build-2784847793"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Histiocytic sarcoma (HS) is a highly metastatic cancer, and while response to several chemotherapy agents has been studied, the outcome remains poor. Vinorelbine (VNB) has been considered a possible treatment option, but data are limited. The aim of this study was to assess the efficacy and toxicity of VNB in canine HS. Medical records of dogs with HS, treated with VNB as first\u2010line or rescue treatment, were reviewed. Overall response rate (ORR), progression\u2010free survival (PFS), overall survival post\u2010VNB (post.VNB.OST) and adverse events were evaluated. Associations between outcome measures and signalment, disease extent\/location, diagnostic modality and response to previous chemotherapies were analysed. Eighteen dogs were included: 12 disseminated and six localised HS. VNB was a rescue treatment in all dogs. ORR was 38.9% [two complete responses (CR), five partial responses (PR)] including two dogs showing delayed best responses. Median PFS and post\u2010VNB\u2010OST for all dogs were 49 (95% CI: 33\u2013166) and 75.5\u2009days (95% CI: 55\u2013174), respectively. Responders showed significantly longer median PFS (120\u2009days) compared to non\u2010responders (41\u2009days). None of the other factors analysed were associated with ORR, PFS and post\u2010VNB\u2010OST, including pulmonary location. Neutropenia and gastrointestinal toxicity were common; however, the majority were low\u2010grade with no hospitalisation required. Vinorelbine can be an effective and safe treatment for canine HS; disease location alone may not be a key predictive factor for VNB response and outcome. Further prospective studies on larger cohorts are required to confirm these findings.<\/jats:p>","DOI":"10.1111\/vco.13060","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T07:28:29Z","timestamp":1745306909000},"page":"358-365","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Vinorelbine as a Rescue Treatment for Canine Histiocytic Sarcoma: A Multicentre Retrospective Study of 18 Dogs"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1054-0206","authenticated-orcid":false,"given":"Nina","family":"Vigevani","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Science, Institute of Infection, Veterinary and Ecological Sciences University of Liverpool  Neston UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3062-4303","authenticated-orcid":false,"given":"Carmit","family":"Chalfon","sequence":"additional","affiliation":[{"name":"Centro Veterinario Torinese  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Guill\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Services, Royal Veterinary College University of London  Hatfield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7843-615X","authenticated-orcid":false,"given":"Laura","family":"Marconato","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Amores\u2010Fuster","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Science, Institute of Infection, Veterinary and Ecological Sciences University of Liverpool  Neston UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1019-9503","authenticated-orcid":false,"given":"Jean\u2010Benoit","family":"Tanis","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Science, Institute of Infection, Veterinary and Ecological Sciences University of Liverpool  Neston UK"},{"name":"Department of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1932-211X","authenticated-orcid":false,"given":"Riccardo","family":"Finotello","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Science, Institute of Infection, Veterinary and Ecological Sciences University of Liverpool  Neston UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2022.07.010"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098258"},{"issue":"1","key":"e_1_2_10_4_1","first-page":"7","article-title":"Morphological Distinction of Histiocytic Sarcoma From Other Tumor Types in Bernese Mountain Dogs and Flatcoated Retrievers","volume":"32","author":"Erich S. 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