{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:12:47Z","timestamp":1789071167884,"version":"build-2803163510"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n Canine infiltrative lipomas are localised and invasive tumours that are commonly treated with surgery and\/or radiation therapy (RT). There is limited efficacy data for treatment of infiltrative lipomas, and optimal fractionation strategies remain unclear. We retrospectively assessed the outcomes and prognostic factors in a cohort of dogs that underwent intensity modulated or three\u2010dimensional conformal RT for infiltrative lipoma. Twenty\u2010nine dogs were included from four academic institutions. The median total radiation dose prescribed and delivered was 51\u2009Gy (range\u2009=\u200920\u201357\u2009Gy). Dose per fraction ranged from 2.4 to 4.2\u2009Gy, with a median of 3\u2009Gy. Median progression\u2010free survival (PFS) was 1483\u2009days; the median overall survival (OS) was 1483\u2009days. Disease progression was documented in four dogs (14%), all of which received less than 51\u2009Gy (range\u2009=\u200920\u201350\u2009Gy). Grade V adverse events (AEs) or secondary malignancies were recorded in six dogs (21%; two bones, one skin, one lungs, one urethra and one small intestine AE); assigned attribution was definite (\n n<\/jats:italic>\n \u2009=\u20091), probable (\n n<\/jats:italic>\n \u2009=\u20092), possible (\n n<\/jats:italic>\n \u2009=\u20092) and unlikely (\n n<\/jats:italic>\n \u2009=\u20091). Gross tumour volume (GTV) was prognostic for PFS (\n p<\/jats:italic>\n \u2009<\u20090.01) while both GTV (\n p<\/jats:italic>\n \u2009<\u20090.01) and total radiation dose (\n p<\/jats:italic>\n \u2009<\u20090.01) were prognostic for OS (\n p<\/jats:italic>\n \u2009<\u20090.01). The number of surgeries and tumour location were not associated with PFS or OS. These findings support the use of RT for long\u2010term local control for unresectable or incompletely excised canine infiltrative lipomas. A higher total radiation dose may result in better long\u2010term local disease control.\n <\/jats:p>","DOI":"10.1111\/vco.13065","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:53:29Z","timestamp":1747194809000},"page":"401-411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Outcome and Prognostic Factors of Dogs Treated for Infiltrative Lipoma Undergoing Radiation Therapy: A Retrospective Multi\u2010Institutional Study of 29 Cases"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8314-5656","authenticated-orcid":false,"given":"Arata","family":"Matsuyama","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences Western College of Veterinary Medicine, University of Saskatchewan Saskatoon Saskatchewan Canada"},{"name":"Department of Biomedical Sciences Ontario Veterinary College, University of Guelph Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0170-3934","authenticated-orcid":false,"given":"Valerie J.","family":"Poirier","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies Ontario Veterinary College, University of Guelph Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Turek","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences School of Veterinary Medicine, University of Wisconsin\u2010Madison Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0793-9005","authenticated-orcid":false,"given":"Valeria S.","family":"Meier","sequence":"additional","affiliation":[{"name":"Clinic of Radiation Oncology and Medical Oncology, Small Animal Department Vetsuisse Faculty, University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8315-1909","authenticated-orcid":false,"given":"Jessica","family":"Lawrence","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine, University of Minnesota St Paul Minnesota USA"},{"name":"Department of Surgical and Radiological Sciences School of Veterinary Medicine, University of California Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098588001700305"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098587901600519"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1994.205.02.322"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740\u20108261.2000.tb01889.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.23.05.0288"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.13001"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740\u20108261.2001.tb00928.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.13291"},{"key":"e_1_2_7_10_1","first-page":"349","article-title":"Analyzing the Usage of Standards in Radiation Therapy Clinical Studies","author":"Zhen Y.","year":"2017","journal-title":"IEEE EMBS International Conference on Biomedical and Health Informatics"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(95)00057-6"},{"key":"e_1_2_7_12_1","unstructured":"National Institute of Health. National Cancer Institute \u201cCTEP\u2014Cancer Therapy Evaluation Program \u201daccessed April 11 2025 https:\/\/ctep.cancer.gov\/protocoldevelopment\/electronic_applications\/ctc.htm."},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-020-09213-y"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2001.tb00973.x"}],"container-title":["Veterinary and Comparative Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.13065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T03:02:23Z","timestamp":1756177343000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vco.13065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,14]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/vco.13065"],"URL":"https:\/\/doi.org\/10.1111\/vco.13065","archive":["Portico"],"relation":{},"ISSN":["1476-5810","1476-5829"],"issn-type":[{"value":"1476-5810","type":"print"},{"value":"1476-5829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,14]]},"assertion":[{"value":"2025-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}