{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T03:40:03Z","timestamp":1756179603038,"version":"3.44.0"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Haematological cancer types, such as leukaemia and lymphoma, represent diseases that are life\u2010threatening to canine and human patients alike, and better treatments are needed. We are developing a novel anticancer agent, NEO212, a conjugate of two cancer drugs, the alkylating agent temozolomide (TMZ) and the monoterpene perillyl alcohol (POH). NEO212 has revealed robust therapeutic activity in preclinical tumour models harbouring different human cancer types. In the comparative preclinical study presented here, a two\u2010species (canine and human) and two\u2010cancer (leukaemia and lymphoma) analysis was performed to determine whether the promising therapeutic activity of NEO212 would span species and cancer types. We investigated the activity of NEO212 in human and canine leukaemia and lymphoma cell lines in\u00a0vitro and in corresponding mouse models in\u00a0vivo. Our results show that in\u00a0vitro NEO212 is significantly more potent than TMZ and POH in all cell lines and exerts activity even against strongly TMZ\u2010resistant tumour cells. In\u00a0vivo, oral NEO212 strikingly extends the survival of mice harbouring human or canine leukaemia or lymphoma cells. At the same time, NEO212 is well tolerated in dogs at dosages higher than those that achieved therapeutic activity in mouse models. Our study introduces NEO212 as a novel oral cancer drug candidate for both human and veterinary oncology applications.<\/jats:p>","DOI":"10.1111\/vco.13066","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T07:20:40Z","timestamp":1747380040000},"page":"412-423","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Potent Therapeutic Activity of <scp>NEO212<\/scp> in Preclinical Models of Human and Canine Leukaemia and Lymphoma"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2183-4667","authenticated-orcid":false,"given":"Thomas C.","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Keck School of Medicine University of Southern California (USC)  Los Angeles California USA"},{"name":"USC\/Norris Comprehensive Cancer Center  Los Angeles California USA"},{"name":"NeOnc Technologies, Inc.  Westlake Village California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1366-1871","authenticated-orcid":false,"given":"Steve","family":"Swenson","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Keck School of Medicine University of Southern California (USC)  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thu Zan","family":"Thein","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Keck School of Medicine University of Southern California (USC)  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0929-6480","authenticated-orcid":false,"given":"Radu O.","family":"Minea","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Keck School of Medicine University of Southern California (USC)  Los Angeles California USA"},{"name":"USC\/Norris Comprehensive Cancer Center  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0662-5653","authenticated-orcid":false,"given":"Axel H.","family":"Sch\u00f6nthal","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology Keck School of Medicine, USC  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101373"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-13-0882"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/noajnl\/vdaa160"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-13-0964"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155826"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16234003"},{"issue":"5","key":"e_1_2_9_8_1","first-page":"1580","article-title":"Preclinical Development and Clinical Use of Perillyl Alcohol for Chemoprevention and Cancer Therapy","volume":"5","author":"Chen T. 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