{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:53:46Z","timestamp":1791222826651,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Canine cardiac hemangiosarcoma (cHSA) represents a complex clinical challenge in that those afflicted have an acute risk of death due to cardiac tamponade and high morbidity and mortality given the frequency of metastasis. Previous studies show that radiation therapy (RT) can decrease the risk of tamponade; however, an optimal approach has yet to be determined. The objective of this study was to evaluate the outcomes of dogs with presumptive cHSA treated with varied RT protocols and modalities, and to contrast findings with previously published literature. Secondary objectives were to assess differences in outcomes between those that received chemotherapy post\u2010RT or did not, single fraction versus multiple\u2010fraction RT protocols, and CT\u2010guided versus manually calculated treatment plans. Twenty\u2010seven dogs with echocardiographic evidence of an atrial or auricular cardiac mass that received RT were included. The frequency of pericardiocentesis before and post\u2010RT were compared. Overall survival time was determined, along with survival time specific to those that received chemotherapy, were treated with CT\u2010based radiation plans, and were prescribed a single fraction versus multiple fractions. Pericardiocentesis was performed an average of 1.1 times per week before RT, and an average of 0.18 times per week after RT (<jats:italic>p<\/jats:italic>\u2009=\u20090.01). Median overall survival time was 137\u2009days. Plans made without CT guidance were associated with more adverse radiation events, but all were minimally impactful on quality of life. Most dogs died or were euthanized due to metastatic disease. This study shows similar benefits to previously published data in a larger cohort of dogs using a less\u2010conformal radiation modality. As well, it highlights future directions to identify optimal systemic therapies to delay the onset of metastasis.<\/jats:p>","DOI":"10.1111\/vco.13068","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T03:29:17Z","timestamp":1748575757000},"page":"432-441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Retrospective Study Evaluating Outcomes Following Palliative Radiotherapy With or Without Chemotherapy for Dogs With Presumed Cardiac Hemangiosarcoma"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8810-5346","authenticated-orcid":false,"given":"Cory N.","family":"Wakamatsu","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine and Biomedical Sciences, Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brianna M.","family":"Potter","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine and Biomedical Sciences, Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Del","family":"Leary","sequence":"additional","affiliation":[{"name":"Department of Environmental and Radiological Health Sciences College of Veterinary Medicine and Biomedical Sciences, Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary\u2010Keara","family":"Boss","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine and Biomedical Sciences, Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9258-4861","authenticated-orcid":false,"given":"Tiffany W.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine and Biomedical Sciences, Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1988.tb01907.x"},{"issue":"5","key":"e_1_2_11_3_1","first-page":"336","article-title":"Concurrent Splenic and Right Atrial Mass at Presentation in Dogs With HSA: A Retrospective Study","volume":"47","author":"Boston S. 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