{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T16:16:44Z","timestamp":1763137004500,"version":"3.45.0"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hypofractionated radiotherapy (hRT) is often used to treat dogs with oral malignant melanoma (OMM); however, there is no consensus as to whether clinically uninvolved regional lymph nodes should be prophylactically irradiated. The objective of this retrospective study is to compare outcomes for dogs with OMM treated with hRT+\/\u2013 elective nodal irradiation (ENI). Dogs with nonmetastatic OMM undergoing hRT+\/\u2013 ENI with a prescription of \u2265\u200930\u2009Gy were included. Survival statistics were evaluated with Kaplan\u2013Meier curves and log\u2010rank testing. Univariable and multivariable Cox proportional hazard models were used to assess how survival was impacted by the use of ENI, WHO T\u2010stage, mitotic count, RT technique, and use of Oncept melanoma vaccine. Data from four institutions and 100 dogs (80 with ENI and 20 without) were included. In the ENI group, nodal and distant metastases were documented in 4 and 30 dogs, respectively. In the non\u2010ENI group, nodal and distant metastases were documented in 6 and 4 dogs, respectively. There was no significant difference in the 1\u2010year nodal or distant progression\u2010free intervals (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.174, and 0.563, respectively). The only variable maintaining significance on multivariable analysis was T\u2010stage (overall progression\u2010free survival, HR 1.393,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006; overall survival time, HR 1.426,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.005; distant progression\u2010free interval, HR 1.521,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.033). ENI did not measurably alter the oncologic outcomes in this study population. Results should be interpreted cautiously given the lack of standardised staging\/restaging and the heterogenous nature of this clinical population. Future investigations are needed to clarify the role of ENI in the treatment of canine OMM.\n                  <\/jats:p>","DOI":"10.1111\/vco.70005","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T05:10:51Z","timestamp":1752815451000},"page":"518-527","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating the Impact of Elective Nodal Irradiation for Dogs With Oral Malignant Melanoma Undergoing Hypofractionated Radiotherapy"],"prefix":"10.1111","volume":"23","author":[{"given":"Patricia","family":"Gualtieri","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Group","sequence":"additional","affiliation":[{"name":"Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Ruslander","sequence":"additional","affiliation":[{"name":"BluePearl Pet Hospital  Cary North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4432-9700","authenticated-orcid":false,"given":"Michael W.","family":"Nolan","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine North Carolina State University  Raleigh North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary\u2010Keara","family":"Boss","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201034676\u2010w"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49873-y"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-3427"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(20)30472\u20101"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2021.6036"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002\u20109610(05)80109\u20106"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.05.035"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.111.1.66"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12541"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.68.581"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12517"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12815"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2023.1202265"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12229"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2003.222.1234"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12415"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12651"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985817698209"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/089875640201900301"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12256"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069222"},{"volume-title":"The Lymphatic System of the Dog","year":"2021","author":"Baum H.","key":"e_1_2_11_23_1"},{"key":"e_1_2_11_24_1","first-page":"517","article-title":"Lymph Pathways of the Medial Retropharyngeal Lymph\u2010Node in Dogs","volume":"186","author":"Belz G. 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