{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T09:19:51Z","timestamp":1787822391262,"version":"build-2784847793"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100031492","name":"Kennel Club Charitable Trust","doi-asserted-by":"publisher","award":["90306"],"award-info":[{"award-number":["90306"]}],"id":[{"id":"10.13039\/100031492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cancer is a leading cause of mortality in older dogs. Despite the prevalence of chemotherapy in canine oncology, a good understanding of owners' observations of side effects and clinical signs in real time is still lacking. Owners' perceptions and reporting of clinical signs play an important role in monitoring a dog's condition during treatment and the use of digital owner\u2010reported outcome measures could prove efficient in tracking chemotherapy side effects in the home environment. This could improve care and draws inspiration from the human use of patient\u2010reported outcome measures in oncology. We aimed to develop and test a prototype digital measure for monitoring clinical signs and health\u2010related quality of life in dogs undergoing chemotherapy, designed to facilitate owner participation in monitoring and support veterinary care. A rapid literature review was conducted to identify existing measures and their methodological limitations. Items were generated based on the Veterinary Comparative Oncology Group\u2010Common Terminology Criteria for Adverse Events, existing client\u2010reported outcome measures, and expert veterinary opinion. Proof\u2010of\u2010Concept testing was performed with 29 dog owners with pets undergoing chemotherapy. Participants completed daily assessments of their dog's clinical signs and weekly quality of life surveys over a 21\u2010day period. A sub\u2010sample participated in cognitive interviews to assess content validity and acceptability. Descriptive statistics were used to assess clinical signs and quality of life scores. Internal consistency and item discrimination were evaluated, and qualitative data were analyzed thematically. High adherence was reported, with a median of 21 daily and 3 weekly assessments completed. Participants found the assessments acceptable and beneficial. Fatigue, polydipsia, and anorexia were the most frequently reported clinical signs. Dogs experienced a median of 3 different clinical signs. The quality\u2010of\u2010life scale showed good internal consistency (Cronbach's\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2009=\u20090.84). Participants appreciated the daily assessments, found them easy to complete, and believed the measure could help improve monitoring and decision\u2010making during chemotherapy. The prototype tool, the Canine Cancer Outcome Measure (CAN\u2010COM), demonstrated feasibility and acceptability for use by owners in the home environment for dogs undergoing chemotherapy. With further refinement and validation, such a tool could improve the monitoring of adverse events and support decision\u2010making in veterinary oncology, enhancing the welfare of canine cancer patients.\n                  <\/jats:p>","DOI":"10.1111\/vco.70028","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T23:41:11Z","timestamp":1762558871000},"page":"80-94","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development and Testing of an Owner\u2010Reported Outcome Measure of Clinical Signs and Quality of Life in Dogs Treated With Chemotherapy"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8933-117X","authenticated-orcid":false,"given":"Jenny","family":"Harris","sequence":"first","affiliation":[{"name":"Faculty of Health and Medical Sciences School of Health Sciences, University of Surrey  Guildford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4544-1454","authenticated-orcid":false,"given":"Katie","family":"Sutton","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences School of Health Sciences, University of Surrey  Guildford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3219-9459","authenticated-orcid":false,"given":"Quentin","family":"Fournier","sequence":"additional","affiliation":[{"name":"Lumbry Park Veterinary Specialists  Alton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7994-0796","authenticated-orcid":false,"given":"Jo","family":"Armes","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences School of Health Sciences, University of Surrey  Guildford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5436-8036","authenticated-orcid":false,"given":"Emma","family":"Ream","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences School of Health Sciences, University of Surrey  Guildford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5190-5342","authenticated-orcid":false,"given":"Nicholas","family":"Bacon","sequence":"additional","affiliation":[{"name":"AURA Veterinary  Guildford UK"},{"name":"Faculty of Health and Medical Sciences, School of Veterinary Medicine University of Surrey  Guildford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40575-018-0066-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12782"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.249.9.1079"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani7030018"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-025-04522-4"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.5948"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.233.1.104"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2010.0583.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.242.12.1679"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.252.9.1073"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12460"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12242"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2021.733812"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.233.8.1278"},{"key":"e_1_2_10_16_1","first-page":"374","article-title":"Real Time Remote Symptom Monitoring During Chemotherapy for Cancer: European Multicentre Randomised Controlled Trial (eSMART)","author":"Maguire R.","year":"2021","journal-title":"BMJ"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.63.0830"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.02015"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.36.15_suppl.6500"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2019.02.005"},{"key":"e_1_2_10_21_1","unstructured":"J. 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