{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T09:19:48Z","timestamp":1787822388185,"version":"build-2784847793"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Stereotactic body radiation therapy (SBRT) has become a non\u2010invasive alternative option for canine adrenal tumours with high surgical risks; however, its clinical benefits and risks are still to be fully understood. The goal of this multi\u2010institutional retrospective study was to describe the clinical outcome and safety of SBRT for the treatment of 21 dogs with adrenal tumours. Ten were suspected pheochromocytomas, two adenocarcinomas, and the diagnosis was unknown in nine dogs. Vascular invasion was present in 81% of cases (17\/21). Thirteen dogs received 3 fractions of 6 to 11\u2009Gy, 7 received 5 fractions of 6 to 9\u2009Gy, and 1 received 4 fractions of 6\u2009Gy. For the 20 patients with follow\u2010up imaging, 9 (43%) had partial response, 10 (47%) stable disease, and 1 (5%) progressive disease. Progression\u2010free survival was 16.8\u2009months (95% CI: 3.4\u201323), and overall survival time was 16.8\u2009months (95% CI: 3.7\u201323.7). Twelve patients (57%) experienced acute adverse events (AEs); of those, seven were gastrointestinal grade \u2265\u2009III, including one grade V. Late AEs were suspected in seven dogs (33%), including gastrointestinal grade V in four of them. A total of five dogs (24%) died from radiation\u2010related toxicities. Although SBRT seems to be effective against adrenal tumours, it was associated with a high morbidity and mortality rate, suggesting that re\u2010evaluation of radiation therapy protocols is necessary for maintaining patient safety.<\/jats:p>","DOI":"10.1111\/vco.70035","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T07:30:14Z","timestamp":1766043014000},"page":"150-159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Outcome and Toxicity Profile of Stereotactic Body Radiation Therapy for Adrenal Tumours in Dogs"],"prefix":"10.1111","volume":"24","author":[{"given":"Lily","family":"Thorsen","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences, College of Veterinary Medicine University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberley","family":"Law","sequence":"additional","affiliation":[{"name":"MSPCA\u2014Angell Animal Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3452-5895","authenticated-orcid":false,"given":"Jillian","family":"Walz","sequence":"additional","affiliation":[{"name":"MSPCA\u2014Angell Animal Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie Morales","family":"Coll","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine &amp; Surgery, College of Veterinary Medicine University of Missouri  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ada","family":"Naramor","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine &amp; Surgery, College of Veterinary Medicine University of Missouri  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2075-3926","authenticated-orcid":false,"given":"Charles","family":"Maitz","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine &amp; Surgery, College of Veterinary Medicine University of Missouri  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyndsay","family":"Kubicek","sequence":"additional","affiliation":[{"name":"Colorado Animal Specialty &amp; Emergency  Boulder Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9175-8789","authenticated-orcid":false,"given":"Zebulon","family":"Thorsen","sequence":"additional","affiliation":[{"name":"North Shore Center for Medical Aesthetics, LTD  Northbrook Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jishnu Rao","family":"Gutti","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, College of Veterinary Medicine University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9509-0528","authenticated-orcid":false,"given":"Marilia","family":"Takada","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, College of Veterinary Medicine University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.242.12.1715"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2003.223.654"},{"key":"e_1_2_11_4_1","volume-title":"Withrow and MacEwen's Small Animal Clinical Oncology","author":"Withrow S. 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