{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:25:49Z","timestamp":1793255149584,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100011782","name":"Western College of Veterinary Medicine, University of Saskatchewan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011782","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Lymph node (LN) metastasis has been associated with shorter survival times in dogs with mast cell tumour (MCT), and treatment of metastatic LN with lymphadenectomy or irradiation has been demonstrated to improve outcomes. Identification of metastatic LN in dogs with MCT is therefore of both prognostic and therapeutic significance. The aim of this prospective, exploratory study was to investigate whether fluorine\u201018 fluorodeoxyglucose\u2010positron emission tomography\/computed tomography (\n                    <jats:sup>18<\/jats:sup>\n                    F\u2010FDG\u2010PET\/CT) is a useful staging tool for the detection of metastatic LN in dogs with cutaneous or subcutaneous MCT, using histopathology as the gold standard. Sixteen client\u2010owned dogs with cytologically or histologically confirmed cutaneous or subcutaneous MCTs underwent full\u2010body\n                    <jats:sup>18<\/jats:sup>\n                    F\u2010FDG\u2010PET\/CT followed by surgical removal and histopathology of the primary tumour and regional LN(s). The maximum standard uptake value (SUV\n                    <jats:sub>max<\/jats:sub>\n                    ) of the tumour and LN(s) was measured. Primary tumours were graded using both the Patnaik and Kiupel grading systems, and mitotic count was tabulated. LNs were categorised based on Weishaar's histologic criteria for nodal metastasis. Eighteen primary tumours were excised: six subcutaneous and 12 cutaneous MCTs. Of 33 excised regional LNs, 18 (55%) were categorised as metastatic (\u2265\u2009HN2). There was no difference between the median SUV\n                    <jats:sub>max<\/jats:sub>\n                    of metastatic (3.88) and nonmetastatic LNs (3.16) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.41). SUV\n                    <jats:sub>max<\/jats:sub>\n                    was positively correlated with the mitotic count of the primary tumour (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02). The results of this exploratory study suggest that\n                    <jats:sup>18<\/jats:sup>\n                    F\u2010FDG\u2010PET\/CT may not be useful for identifying metastatic LNs in canine MCT.\n                  <\/jats:p>","DOI":"10.1111\/vco.70040","type":"journal-article","created":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T06:30:18Z","timestamp":1766817018000},"page":"197-207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Fluorine\u201018 Fluorodeoxyglucose\u2010Positron Emission Tomography\/Computed Tomography for Detection of Lymph Node Metastasis in Canine Mast Cell Tumour"],"prefix":"10.1111","volume":"24","author":[{"given":"Alison C.","family":"Williams","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine University of Saskatchewan  Saskatoon Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3414-3918","authenticated-orcid":false,"given":"Monique N.","family":"Mayer","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine University of Saskatchewan  Saskatoon Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan M.","family":"Dickinson","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, Western College of Veterinary Medicine University of Saskatchewan  Saskatoon Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally L.","family":"Sukut","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine University of Saskatchewan  Saskatoon Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie S.","family":"MacDonald\u2010Dickinson","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine University of Saskatchewan  Saskatoon Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Gagnon","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine University of Saskatchewan  Saskatoon Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-59496-7.00021-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-5557"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.246.7.765"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2009.00185.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12425"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12541"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2002.tb01023.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12408"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12256"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12636"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-021-03043-0"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.14246"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12861"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2019.07.001"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0172651"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2010.01757.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2015.12.008"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2009.01520.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098588402100503"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810386469"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810387446"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2014.07.004"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.13002"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12323"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.228.11.1718"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40644-018-0165-5"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.5152\/tao.2015.608"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0000000000000198"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-007-0097-9"},{"issue":"2","key":"e_1_2_10_31_1","first-page":"131","article-title":"Retrospective 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