{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:28:42Z","timestamp":1791772122912,"version":"4.3.4"},"reference-count":88,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Pet dogs with naturally occurring cancers provide valuable models for comparative oncology and pathology tumour registries offer a powerful resource for onco\u2010epidemiological research. Here, we analysed the Small Animal Veterinary Surveillance Network (SAVSNET) pathology\u2010based tumour registry (PTR), one of the largest veterinary tumour registries to date, focusing on four major canine tumours: mast cell tumour (MCT), osteosarcoma (OSA), haemangiosarcoma (HSA), and melanoma (MEL). A case\u2013control study was conducted using a subset of 130\u2009998 histologically confirmed tumours drawn from the pathology tumour registry containing over 1.1 million canine tumour records from 1.02 million dogs collected in the UK between 2010 and 2023. Case\u2013control analyses were performed for melanoma, haemangiosarcoma, OSA and MCT using a denominator population of dogs attending first\u2010opinion veterinary practices. Additionally for MCT, comparisons were made against dogs diagnosed with other tumour types (\u2018tumour denominator\u2019 approach). Breed\u2010specific risks were identified, including high odds ratios (OR) for Bulldog\u2010related breeds and Retrievers with mast cell tumours (MCTs) (OR up to 6.8, 95% CI 6.0, 7.6), Rottweilers, Shar Pei and Giant\u2010Schnauzer with melanoma (OR up to 50.3, 95% CI 24.7, 102.5), and German Shepherd Dogs, Mastiffs, and Bullmastiffs with haemangiosarcoma (OR up to 28.0, 95% CI 10.6, 40.9). Higher\u2010grade MCT were diagnosed at older ages and certain breeds were more predisposed to higher\u2010grade MCT (Shar Pei, Rottweiler) while others were more prone to low\u2010grade MCTs (Boxer, Boston Terrier). Neutered dogs generally had higher tumour odds than entire dogs; for example, in MCTs, female\u2010neutered vs. female\u2010entire showed OR 1.81 (95% CI 1.6, 2.0) in ages 3\u20136, with similar patterns across older age bands. In general, the difference in OR values between entire and neutered dogs was consistently more pronounced in females than in males. These findings demonstrate the value of the SAVSNET PTR as a comprehensive resource for canine tumour surveillance, with potential to support health initiatives and cancer research by identifying breed\u2010specific and demographic risk factors as well as a foundational tool for comparative cancer epidemiology.<\/jats:p>","DOI":"10.1111\/vco.70056","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T09:53:57Z","timestamp":1772963637000},"page":"324-340","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Epidemiology of Four Major Canine Tumours in the\n                    <scp>UK<\/scp>\n                    : Insights From a National Pathology Registry With Comparative Oncology Perspectives"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8997-0350","authenticated-orcid":false,"given":"Jos\u00e9","family":"Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Institute for Animal Health and Food Safety University of Las Palmas de Gran Canaria  Las Palmas Spain"},{"name":"Institute of Infection, Veterinary and Ecological Sciences University of Liverpool  Neston UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Espinosa","family":"de los Monteros","sequence":"additional","affiliation":[{"name":"Institute for Animal Health and Food Safety University of Las Palmas de Gran Canaria  Las Palmas Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngelo","family":"Santana","sequence":"additional","affiliation":[{"name":"Mathematics Department University of Las Palmas de Gran Canaria  Las Palmas Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. J.","family":"Noble","sequence":"additional","affiliation":[{"name":"Institute of Infection, Veterinary and Ecological Sciences University of Liverpool  Neston UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4590-1334","authenticated-orcid":false,"given":"Alan D.","family":"Radford","sequence":"additional","affiliation":[{"name":"Institute of Infection, Veterinary and Ecological Sciences University of Liverpool  Neston UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Cian","sequence":"additional","affiliation":[{"name":"Batt Laboratories, Venture Centre  Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Veterinary Pathology Group (VPG)  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny S.","family":"McKay","sequence":"additional","affiliation":[{"name":"Veterinary Pathology Group (VPG)  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Jones","sequence":"additional","affiliation":[{"name":"IDEXX Laboratories  Wetherby West Yorkshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Killick","sequence":"additional","affiliation":[{"name":"Institute of Infection, Veterinary and Ecological Sciences University of Liverpool  Neston UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2014.0231"},{"key":"e_1_2_16_3_1","first-page":"2022","volume-title":"Companion Animals as Sentinels for Predicting Environmental Exposure Effects on Aging and Cancer Susceptibility in Humans Proceedings of a Workshop","author":"National Academies of Sciences E"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-023-00977-3"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.150274"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2024.106155"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2013.09.020"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40575-020-00086-8"},{"key":"e_1_2_16_9_1","unstructured":"Grand View Research \u201cVeterinary Oncology Market Size Share & Trends Analysis Report By Therapy (Radiotherapy Surgery) By Animal Type (Canine Feline) By Cancer Type By Region And Segment Forecasts 2024\u20132030 \u201d2022 accessed September 23 2024 https:\/\/www.grandviewresearch.com\/industry\u2010analysis\/veterinary\u2010oncology\u2010market."},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12577"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-021-01039-x"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.l6074"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0302231"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes10070501"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.6377"},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/vetr.585"},{"key":"e_1_2_16_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.6235"},{"key":"e_1_2_16_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1250766"},{"key":"e_1_2_16_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci6020048"},{"key":"e_1_2_16_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34163"},{"key":"e_1_2_16_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/2052-6687-2-1"},{"key":"e_1_2_16_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2022.07.009"},{"key":"e_1_2_16_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-017-1126-0"},{"key":"e_1_2_16_24_1","doi-asserted-by":"crossref","unstructured":"L. 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