{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T06:09:19Z","timestamp":1778998159744,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Primary mediastinal lymphoma is rare in dogs and literature exploring this disease is limited. Therefore, the aim of this study was to describe presentation, treatment and outcome in a large cohort of dogs with mediastinal lymphoma and explore prognostic factors including chemotherapy protocol. This retrospective multi\u2010institute study included 70 dogs with primary mediastinal lymphoma treated with lomustine\u2010based (LOP\/LOPP) or anthracycline\u2010based (CHOP\/CEOP) chemotherapy. Most immunophenotyped cases were of T\u2010cell lineage (95.6%). The majority were substage\n                    <jats:italic>b<\/jats:italic>\n                    (90%) and hypercalcaemia was noted in 69.1% of dogs. Clinical and objective response rates to chemotherapy were 92.7% and 97.9%, respectively, with 76.6% of dogs achieving a complete response. Median progression free survival (PFS) was 132\u2009days (95% CI 83\u2013181), and median overall survival time (OST) was 223\u2009days (95% CI 175\u2013271). The 6\u2010month, 1\u2010year, and 2\u2010year survival rates were 55.7%, 22.9%, and 15.7%, respectively. On multivariable analysis, factors associated with longer PFS included hypercalcaemia (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.041), chemotherapy\u2010induced neutropenia (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.014) and CD4+\/CD8\u2212 immunophenotype (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004). Neutropenia at diagnosis was associated with shorter PFS (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.015) and OST (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004). Other factors associated with shorter OST included granular morphology (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.023) and CD4+\/CD8+ immunophenotype (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004). Chemotherapy\u2010induced neutropenia was associated with improved OST (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.042). Differences in outcome between anthracycline\u2010 or lomustine\u2010based chemotherapy protocols were not statistically significant. Overall, the prognosis for primary mediastinal lymphoma in dogs is poor to fair when treated with multi\u2010agent chemotherapy. This is the second study associating hypercalcaemia with improved PFS in dogs with non\u2010indolent T\u2010cell lymphoma. Results also suggest prognostic significance of specific CD4\/CD8 expression patterns.\n                  <\/jats:p>","DOI":"10.1111\/vco.70062","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T11:51:46Z","timestamp":1774957906000},"page":"382-392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mediastinal Lymphoma in 70 Dogs Treated With Lomustine or Anthracycline\u2010Based Multi\u2010Agent Chemotherapy"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1912-2679","authenticated-orcid":false,"given":"Diogo","family":"Machado","sequence":"first","affiliation":[{"name":"Department of Clinical Science and Services Royal Veterinary College  Hatfield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Alvarez","family":"Picornell","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences University of Liverpool  Neston UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Amores\u2010Fuster","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences University of Liverpool  Neston UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9475-4492","authenticated-orcid":false,"given":"Sarah","family":"Benjamin","sequence":"additional","affiliation":[{"name":"Davies Veterinary Specialists  Hitchin UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Kearns","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Queen's Veterinary School Hospital, School of Biological Sciences University of Cambridge  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alenka Lavra","family":"Zajc","sequence":"additional","affiliation":[{"name":"Northwest Veterinary Specialists  Runcorn 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