{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T19:37:08Z","timestamp":1786390628251,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Oral malignant melanoma (OMM) is the most common canine oral neoplasm. Complete excision is recognised as the mainstay of treatment in the absence of distant metastasis, but recommended surgical margins are unvalidated. This study investigates the surgical margins required for complete excision of canine OMMs. We hypothesised that surgical margins 10\u201315\u2009mm wide and a qualitative deep margin (bone, fascia or full\u2010thickness tissue excision) would be adequate for complete local excision of OMMs. Margins required to excise canine oral melanocytomas are also unknown; a secondary objective was to investigate this. Cases were retrospectively collected from two referral centres and a veterinary pathology laboratory. Histologic diagnosis, en bloc excision of gross tumour, surgical margin and histologic margins were required for inclusion. Tumours were categorised based on surgical margin width (Group A\u2009&lt;\u200910\u2009mm, Group B 10\u201315\u2009mm and Group C\u2009&gt;\u200915\u2009mm). A qualitative deep margin was required for Groups B and C, but not Group A, to include marginal excision cases. Histologic margins were classified by the R tumour classification scheme. Twenty\u2010eight tumours were included, comprising 25 OMMs and three melanocytomas. R0 rates for OMMs were 56% (10\/17) in Group A, 100% (7\/7) in Group B and 100% (2\/2) in Group C. Surgical margins\u2009\u2265\u200910\u2009mm were significantly (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03) more likely to result in R0 classification. The three melanocytomas were all classified as R0, with &lt;\u200910\u2009mm surgical margins. Results suggest that surgical margins 10\u201315\u2009mm wide and a qualitative deep margin may be adequate for complete excision of OMMs.\n                  <\/jats:p>","DOI":"10.1111\/vco.70069","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:20:34Z","timestamp":1776385234000},"page":"458-467","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Surgical Margins Required for the Complete Excision of Canine Oral Melanomas"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2504-3377","authenticated-orcid":false,"given":"Jonathon Richard","family":"Chinner","sequence":"first","affiliation":[{"name":"The Austin Vet Specialists  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jovene Jia Wen","family":"Lee","sequence":"additional","affiliation":[{"name":"Gribbles Veterinary Pathology  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1688-8951","authenticated-orcid":false,"given":"Jonathan","family":"Tuke","sequence":"additional","affiliation":[{"name":"Faculty of Sciences, Engineering and Technology, School of Computer and Mathematical Sciences The University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fui Wen","family":"Yap","sequence":"additional","affiliation":[{"name":"The Austin Vet Specialists  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2024.1359426"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci11090435"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-59496-7.00020-7"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748\u20105827.1994.tb03273.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12624"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","unstructured":"S. E.Boston X.Lu W. T. N.Culp et\u00a0al. \u201cEfficacy of Systemic Adjuvant Therapies Administered to Dogs After Excision of Oral Malignant Melanomas: 151 Cases (2001\u20132012) \u201d245 no.4(2014):401\u2013407 https:\/\/doi.org\/10.2460\/javma.245.4.401.","DOI":"10.2460\/javma.245.4.401"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","unstructured":"D.Giacobino M.Camerino F.Riccardo et\u00a0al. \u201cDifference in Outcome Between Curative Intent vs Marginal Excision as a First Treatment in Dogs With Oral Malignant Melanoma and the Impact of Adjuvant CSPG4\u2010DNA Electrovaccination: A Retrospective Study on 155 Cases \u201d19 no.4(2021):651\u2013660 https:\/\/doi.org\/10.1111\/vco.12690.","DOI":"10.1111\/vco.12690"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12284"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119089124.ch6"},{"key":"e_1_2_10_11_1","first-page":"1663","volume-title":"Veterinary Surgery Small Animal","author":"Berg J.","year":"2018"},{"key":"e_1_2_10_12_1","first-page":"331","volume-title":"Small Animal Surgery","author":"Fossum T. 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C.Smedley L.Bongiovanni C.Bacmeister et\u00a0al. \u201cDiagnosis and Histopathologic Prognostication of Canine Melanocytic Neoplasms: A Consensus of the Oncology\u2010Pathology Working Group \u201d20 no.4(2022):739\u2013751 https:\/\/doi.org\/10.1111\/vco.12827.","DOI":"10.1111\/vco.12827"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.45\u20106\u2010889"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.245.11.1266"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12555"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198011000-00013"},{"key":"e_1_2_10_18_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2025"},{"key":"e_1_2_10_19_1","unstructured":"Positron \u201cPosit Software PBC \u201d2025 https:\/\/positron.posit.co."},{"key":"e_1_2_10_20_1","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen J.","year":"1988"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.13619"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci11050226"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12321"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119089124.ch1"},{"key":"e_1_2_10_25_1","doi-asserted-by":"crossref","unstructured":"N. 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P.Chanoit \u201cWhat Is the Value of Statistical Testing of Observational Data? \u201d51 no.7(2022):1043\u20131051 https:\/\/doi.org\/10.1111\/vsu.13845.","DOI":"10.1111\/vsu.13845"}],"container-title":["Veterinary and Comparative Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.70069","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vco.70069","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.70069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T19:04:13Z","timestamp":1786388653000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vco.70069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,16]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/vco.70069"],"URL":"https:\/\/doi.org\/10.1111\/vco.70069","archive":["Portico"],"relation":{},"ISSN":["1476-5810","1476-5829"],"issn-type":[{"value":"1476-5810","type":"print"},{"value":"1476-5829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,16]]},"assertion":[{"value":"2025-11-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}