{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T19:36:59Z","timestamp":1786390619556,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Moderately hypofractionated definitive\u2010intent radiotherapy protocols can be used for canine intracranial meningiomas to shorten overall treatment time while maintaining tumour control and limiting normal tissue toxicity. This retrospective study evaluated oncologic outcomes, toxicity, and radiation dose\u2010volume\u2010related prognostic factors in dogs with imaging\u2010based intracranial meningiomas treated with a 10\u2010fraction definitive\u2010intent protocol. Medical records from 2015 to 2025 were reviewed. All dogs received 10 daily fractions of 4\u2009Gy delivered with a homogeneous dose prescription, risk\u2010adapted heterogeneous dose distributions, or an 11% simultaneously integrated boost (SIB) to the gross tumour volume. One hundred and ten dogs were included, with a median follow\u2010up of 498\u2009days. Median time to progression was 873\u2009days (95% CI: 552\u20131195), median overall survival after first radiotherapy was 756\u2009days (95% CI: 474\u20131039), and median DSS was 1078\u2009days (95% CI: 915\u20131242). Time to progression differed among treatment subgroups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.024). Larger volumes of normal brain receiving \u2265\u200932\u2009Gy (&gt;\u200911.5\u2009cm\n                    <jats:sup>3<\/jats:sup>\n                    ) were associated with shorter overall (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and disease\u2010specific survival (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002). Use of an SIB was associated with shorter disease\u2010specific survival (HR 2.47;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.012), and post\u2010radiotherapy seizures were associated with reduced time to progression (HR 2.01;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.026). Tumour location was not identified as a prognostic factor. Acute or early delayed neurologic toxicity occurred in 10% of dogs and was generally transient and generally corticosteroid responsive. In conclusion, the definitive\u2010intent, moderately hypofractionated 10\u2010fraction radiotherapy protocol achieves long lasting tumour control and survival outcomes in dogs with intracranial meningiomas, provided that evidence\u2010based brain dose\u2010volume constraints are respected.\n                  <\/jats:p>","DOI":"10.1111\/vco.70081","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:44:58Z","timestamp":1781678698000},"page":"601-610","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Definitive\u2010Intent 10\u2010Fraction Radiotherapy Protocol (\u2018The Zurich Protocol\u2019) Yields Lasting Tumour Control and Survival in Dogs With Intracranial Meningiomas"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8747-9098","authenticated-orcid":false,"given":"Carlotta","family":"Ahrens","sequence":"first","affiliation":[{"name":"Clinic for Radiation Oncology &amp; Medical Oncology, University Animal Hospital, Vetsuisse Faculty University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3996-7043","authenticated-orcid":false,"given":"Sergejs","family":"Unterkirhers","sequence":"additional","affiliation":[{"name":"Clinic for Radiation Oncology &amp; Medical Oncology, University Animal Hospital, Vetsuisse Faculty University of Zurich  Zurich Switzerland"},{"name":"Department of Physics University of Zurich  Zurich Switzerland"},{"name":"Radiotherapie Hirslanden AG  Aarau Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5733-2722","authenticated-orcid":false,"given":"Carla","family":"Rohrer Bley","sequence":"additional","affiliation":[{"name":"Clinic for Radiation Oncology &amp; Medical Oncology, University Animal Hospital, Vetsuisse Faculty University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1892\/0891\u20106640"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12054"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12440"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12636"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12129"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15324"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.13040"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12265"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16472"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16431"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12722"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmp.2024.103317"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912\u2010010\u20100143\u2010y"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12118"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.70038"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15695"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.905976"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/noajnl\/vdac110"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.17163"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060\u2010021\u201003853\u20100"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.17213"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3171\/2025.4.JNS242824"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939\u20101676.2008.00042.x"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912\u2010019\u20100818\u2010y"}],"container-title":["Veterinary and Comparative Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.70081","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vco.70081","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.70081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T19:03:47Z","timestamp":1786388627000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vco.70081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,16]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/vco.70081"],"URL":"https:\/\/doi.org\/10.1111\/vco.70081","archive":["Portico"],"relation":{},"ISSN":["1476-5810","1476-5829"],"issn-type":[{"value":"1476-5810","type":"print"},{"value":"1476-5829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,16]]},"assertion":[{"value":"2026-01-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}