{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T04:21:10Z","timestamp":1783138870267,"version":"3.54.6"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Electrochemotherapy is increasingly used as a locoregional treatment for feline squamous cell carcinoma, but its role in advanced nasal planum disease remains poorly defined. This retrospective study evaluated the long\u2010term outcome of ECT as a sole treatment modality in 18 cats with T\n                    <jats:sub>3<\/jats:sub>\n                    \u2013T\n                    <jats:sub>4<\/jats:sub>\n                    N\n                    <jats:sub>0<\/jats:sub>\n                    M\n                    <jats:sub>0<\/jats:sub>\n                    nasal planum squamous cell carcinoma. Adverse events were assessed according to VCOG\u2010CTCAE v2. Response was assessed using RECIST v1.1 criteria, and progression\u2010free survival (PFS), overall survival (OS) and time to progression (TTP) were analysed using Kaplan\u2013Meier methods. At the end of treatment, 72.2% of cats achieved complete response, 16.7% partial response and 11.1% stable disease, resulting in an overall response rate of 88.8%. The 1\u2010year complete response rate was 61.1%. Treatment response was significantly associated with PFS (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006), OS (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and TTP (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006), while recurrence was associated with shorter PFS (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.003) and OS (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002). The 1\u2010year risk of recurrence was 50%. Adverse events were mostly low\u2010grade (VCOG Grade I\u2013II) and self\u2010limiting, the most common being transient local pain, erythema\/crusting and pruritus; no grade \u2265\u20093 complications such as tissue necrosis or fistula formation were observed. These results suggest that ECT is an effective and well\u2010tolerated treatment also in advanced stages nasal planum squamous cell carcinoma, with high response rates and long\u2010term control disease. The risk of recurrence underscores the need for prolonged follow\u2010up, as additional treatment sessions may be performed upon relapse, while ECT can also be used with palliative intent to prolong survival while preserving quality of life.\n                  <\/jats:p>","DOI":"10.1111\/vco.70087","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T04:10:21Z","timestamp":1783138221000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010Term Outcome of Electrochemotherapy in the Treatment of Advanced Stages (\n                    <scp>\n                      T\n                      <sub>3<\/sub>\n                    <\/scp>\n                    \u2013\n                    <scp>\n                      T\n                      <sub>4<\/sub>\n                    <\/scp>\n                    ) of Feline Nasal Planum Squamous Cell Carcinoma"],"prefix":"10.1111","author":[{"given":"Delia","family":"Franchini","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine University of Bari Aldo Moro  Valenzano Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Laino","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine University of Bari Aldo Moro  Valenzano Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0950-3119","authenticated-orcid":false,"given":"Chiara","family":"Perrone","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine University of Bari Aldo Moro  Valenzano Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Di Bello","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine University of Bari Aldo Moro  Valenzano Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Ciccarelli","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine University of Bari Aldo Moro  Valenzano Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X13483238"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X241248043"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X13507071"},{"key":"e_1_2_10_5_1","volume-title":"TNM Classification of Tumours in Domestic Animals","author":"Owen L.","year":"1980"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci8030053"},{"key":"e_1_2_10_7_1","volume-title":"Withrow and MacEwen's Small Animal Clinical Oncology","author":"Vail D.","year":"2019"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2007.08.011"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678\u20104162\u20109060"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2009.10.005"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917\u2010017\u20101018\u20103"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2005.12.003"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2019.04.006"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1892\/0891\u20106640(2007)21[770:ptofcs]2.0.co;2"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201075472\u20100"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12980"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2022.868989"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201013767\u2010w"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X251347152"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12677"},{"issue":"2","key":"e_1_2_10_21_1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3390\/ani12020155","article-title":"Appetite Stimulant and Anti\u2010Emetic Effect of Mirtazapine Transdermal Ointment in Cats Affected by Lymphoma Following Chemotherapy Administration: A Multi\u2010Centre Retrospective Study","volume":"12","author":"Ferro L.","year":"2022","journal-title":"Animals"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12032"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0b013e3181b9c5ec"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(14)70375\u20104"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.5326\/15473317\u201033\u20104\u2010329"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.2478\/raon\u20102013\u20100002"}],"container-title":["Veterinary and Comparative Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.70087","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vco.70087","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.70087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T04:10:23Z","timestamp":1783138223000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vco.70087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,3]]},"references-count":25,"alternative-id":["10.1111\/vco.70087"],"URL":"https:\/\/doi.org\/10.1111\/vco.70087","archive":["Portico"],"relation":{},"ISSN":["1476-5810","1476-5829"],"issn-type":[{"value":"1476-5810","type":"print"},{"value":"1476-5829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,3]]},"assertion":[{"value":"2026-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"vco.70087"}}