{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:14:42Z","timestamp":1788362082502,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100022822","name":"Merck Animal Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100022822","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Gilvetmab is a caninised monoclonal antibody against canine PD\u20101. Concurrent or sequential administration of anti\u2010PD\u20101 antibodies and radiation therapy (RT) improves survival time in various species. Eighteen dogs with mast cell tumours (MCTs) were prospectively treated with 24\u2009Gy of RT over Days 0, 7 and 21 and gilvetmab every 2\u2009weeks beginning on the second fraction of RT (Day 7) for up to 10 doses. Best tumour response was complete in one (6%), partial in eight (44%) and stable disease in nine dogs (50%) for an ORR of 50%. Median time to best response was 7\u2009days after the first fraction of RT. Thirteen dogs (72%) developed progressive disease with a median progression free interval (PFI) of 116\u2009days after the first fraction of RT. Nine adverse events (AEs) attributed to gilvetmab were recorded in seven dogs (39%) consisting of infusion reactions in four, metabolic changes in three and gastrointestinal signs and pancreatitis in one each. Overall, five dogs (28%) experienced Grade 3 AEs. Radiation AEs were limited to Grade 1 for both acute and late effects in seven dogs (39%). There was a significant difference in PFI and MST for dogs with and without lymph node metastasis with a median PFI of 64 versus 292\u2009days and MST of 103 versus 587\u2009days (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02 and 0.005, respectively). This sequence, or combination, of therapies did not provide durable tumour control for canine MCT and the AE profile warrants further evaluation.\n                  <\/jats:p>","DOI":"10.1111\/vco.70110","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T01:16:20Z","timestamp":1788311780000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Combination of Hypofractionated Radiation Therapy and Gilvetmab for the Treatment of Cutaneous or Subcutaneous Mast Cell Tumours in Dogs"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9258-4861","authenticated-orcid":false,"given":"Tiffany W.","family":"Martin","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8914-7767","authenticated-orcid":false,"given":"Douglas H.","family":"Thamm","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen M.","family":"Weishaar","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI67313"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-020-01666-1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15113013"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.12.025"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709937"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-1258"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1988.193.08.936"},{"key":"e_1_2_10_9_1","unstructured":"\u201cCompendium of Veterinary Products\u2014Gilvetmab (MERCK ANIMAL HEALTH) 2013 \u201dhttps:\/\/merckusa.cvpservice.com\/product\/basic\/view\/1047586."},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.13291"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12677"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12032"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2307\/2531495"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5810.2004.00048.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12727"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13028-018-0431-3"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12840"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1181051"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2020.790"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-025-15127-3"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00580-021-03246-9"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2020.100170"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-019-0643-y"},{"key":"e_1_2_10_24_1","volume-title":"TNM Classification of Tumours in Domestic Animals\/ edited by L.N. 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