{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:15:37Z","timestamp":1790248537284,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Carcinomas are the second most common feline intranasal neoplasm. Various treatment options, including radiotherapy, surgery or a combination of both, have been described, but data on medical therapy efficacy are lacking. This retrospective study evaluated the outcome of cats with nasal carcinoma (NC) treated with antineoplastic treatment. Cats with a histopathological or cytopathological diagnosis of NC were included. Patients receiving antineoplastic treatment were compared to patients receiving palliative treatment alone. Response to therapy, median time to progression (MTTP) and median survival time (MST) were described and compared for both groups. Analysed clinical variables included the presence of epistaxis, facial deformity, stage, use of NSAIDs and previous surgical debulking. Thirty\u2010three cats were included in the study: 18 in the antineoplastic treatment group and 15 in the palliative treatment group. Forty\u2010eight percent of the entire population had worsening of the clinical signs, 36% remained stable and 16% showed clinical benefit. MTTP of the entire population was 104\u2009days and MST was 178\u2009days. No statistically significant differences were found between groups for either MTTP (96 vs. 111\u2009days;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.95) or MST (197 vs. 262;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.77). None of the evaluated clinical variables was associated with outcome. In this retrospective study, antineoplastic treatment was not associated with a detectable survival advantage over palliative treatment alone. These findings should be interpreted cautiously given the small sample size and heterogeneity of treatments administered.\n                  <\/jats:p>","DOI":"10.1111\/vco.70117","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:51:08Z","timestamp":1790247068000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tolerability and Outcome of Medical Treatment in Feline Nasal Carcinomas: A Multi\u2010Institutional Retrospective Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7045-9231","authenticated-orcid":false,"given":"Filomena","family":"Amato","sequence":"first","affiliation":[{"name":"Clinica Veterinaria Malpensa AniCura  Samarate Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5100-9644","authenticated-orcid":false,"given":"Matteo","family":"Gobbetti","sequence":"additional","affiliation":[{"name":"Clinica Veterinaria Citt\u00e0 di Monza  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3993-038X","authenticated-orcid":false,"given":"Antonio","family":"Giuliano","sequence":"additional","affiliation":[{"name":"Harvest Veterinary Oncology Center  Kwai Chung Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5081-2440","authenticated-orcid":false,"given":"Elisabetta","family":"Treggiari","sequence":"additional","affiliation":[{"name":"Oncopets  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Pieri","sequence":"additional","affiliation":[{"name":"Clinica Veterinaria Malpensa AniCura  Samarate Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Bonazzi","sequence":"additional","affiliation":[{"name":"Ospedale Veterinario I Portoni Rossi AniCura  Zola Predosa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Luigi","family":"Bianchi","sequence":"additional","affiliation":[{"name":"DocVet  Nerviano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6525-1255","authenticated-orcid":false,"given":"Paola","family":"Valenti","sequence":"additional","affiliation":[{"name":"Clinica Veterinaria Malpensa AniCura  Samarate Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"308","volume-title":"Tumors in Domestic Animals","author":"Moulton J. 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L.","year":"2007","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_9_6_1","first-page":"339","article-title":"Tumors of the Nose and Paranasal Sinuses in Cats: 32 Cases With Comparison to a National Database (1977\u20131987)","volume":"27","author":"Cox N. R.","year":"1991","journal-title":"Journal of the American Animal Hospital Association"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2460\/javma.1996.208.03.385","article-title":"Radiographic Findings in Cats With Intranasal Neoplasms or Chronic Rhinitis: 29 Cases (1982\u20131988)","volume":"208","author":"O'Brien R. 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P.","year":"1994","journal-title":"Journal of the American Veterinary Medical Association"},{"issue":"2","key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1053\/jfms.2001.0159","article-title":"Long\u2010Term Outcome of Eight Cats With Non\u2010Lymphoproliferative Nasal Tumours Treated by Megavoltage Radiotherapy","volume":"4","author":"Mellanby R. J.","year":"2002","journal-title":"Journal of Feline Medicine and Surgery"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1111\/jvim.16098","article-title":"Retrospective Evaluation of Intranasal Carcinomas in Cats Treated With External\u2010Beam Radiotherapy: 42 Cases","volume":"35","author":"Yoshikawa H.","year":"2021","journal-title":"Journal of Veterinary Internal Medicine"},{"issue":"3","key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.tvjl.2014.09.016","article-title":"Evaluation of Outcomes and Radiation Complications in 65 Cats With Nasal Tumours Treated With Palliative Hypofractionated Radiotherapy","volume":"202","author":"Fujiwara\u2010Igarashi A.","year":"2014","journal-title":"Veterinary Journal"},{"issue":"10","key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1177\/1098612X19893445","article-title":"Clinical Response and Survival Time of Cats With Carcinoma of the Nasal Cavity Treated With Palliative Coarse Fractionated Radiotherapy","volume":"22","author":"Giuliano A.","year":"2020","journal-title":"Journal of Feline Medicine and Surgery"},{"key":"e_1_2_9_17_1","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/j.1751-0813.2004.tb12151.x","article-title":"Treatment of Eight Dogs With Nasal Tumours With Alternating Doses of Doxorubicin and Carboplatin in Conjunction With Oral Piroxicam","volume":"82","author":"Langova V.","year":"2004","journal-title":"Australian Veterinary Journal"},{"issue":"1","key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/vco.12443","article-title":"Canine Intranasal Tumors Treated With Alternating Carboplatin and Doxorubicin in Conjunction With Oral Piroxicam","volume":"17","author":"Woodruff M. J.","year":"2019","journal-title":"Veterinary and Comparative Oncology"},{"key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/j.1476-5829.2011.00275.x","article-title":"Preliminary Evidence for Biologic Activity of Toceranib Phosphate (Palladia) in Solid Tumours","volume":"10","author":"London C.","year":"2011","journal-title":"Veterinary and Comparative Oncology"},{"key":"e_1_2_9_20_1","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1111\/jsap.13387","article-title":"Treatment of Advanced\u2010Stage Canine Nasal Carcinomas With Toceranib Phosphate: 23 Cases (2015\u20132020)","volume":"62","author":"Merino\u2010Gutierrez V.","year":"2021","journal-title":"Journal of Small Animal Practice"},{"key":"e_1_2_9_21_1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/vco.12776","article-title":"A Prospective, Multicentre, Veterinary Radiation Therapy Oncology Group Study Reveals Potential Efficacy of Toceranib Phosphate (Palladia) as a Primary or Adjuvant Agent in the Treatment of Canine Nasal Carcinoma","volume":"20","author":"Ehling T. 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C.","year":"2001","journal-title":"Journal of Veterinary Internal Medicine"},{"key":"e_1_2_9_40_1","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/vco.12115","article-title":"Outcome of Definitive Fractionated Radiation Followed by Exenteration of the Nasal Cavity in Dogs With Sinonasal Neoplasia: 16 Cases","volume":"14","author":"Bowles K.","year":"2016","journal-title":"Veterinary and Comparative Oncology"},{"key":"e_1_2_9_41_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13104-018-3190-3","article-title":"Evaluation of Tumor Volume Reduction of Nasal Carcinomas Versus Sarcomas in Dogs Treated With Definitive Fractionated Megavoltage Radiation: 15 Cases (2010\u20132016)","volume":"11","author":"Morgan M. J.","year":"2018","journal-title":"BMC Research Notes"}],"container-title":["Veterinary and Comparative Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.70117","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vco.70117","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.70117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:51:14Z","timestamp":1790247074000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vco.70117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,24]]},"references-count":40,"alternative-id":["10.1111\/vco.70117"],"URL":"https:\/\/doi.org\/10.1111\/vco.70117","archive":["Portico"],"relation":{},"ISSN":["1476-5810","1476-5829"],"issn-type":[{"value":"1476-5810","type":"print"},{"value":"1476-5829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,24]]},"assertion":[{"value":"2026-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"vco.70117"}}