{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:24:22Z","timestamp":1787016262863,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,31]],"date-time":"2012-12-31T00:00:00Z","timestamp":1356912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A 12\u2010year\u2010old, spayed female, mixed\u2010breed dog was presented for acute hematuria, stranguria, polyuria, and polydipsia, as well as lameness for 8\u00a0days. Previous medical history included treatment for infection with\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\n                      hrlichia canis\n                    <\/jats:italic>\n                    ,\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                      naplasma phagocytophilum\n                    <\/jats:italic>\n                    ,\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>\n                      eishmania infantum\n                    <\/jats:italic>\n                    , and\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>\n                      irofilaria immitis\n                    <\/jats:italic>\n                    6.5\u00a0years prior to presentation. Besides persistently increased antibody titers to\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\n                      \u00a0canis\n                    <\/jats:italic>\n                    and\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                      \u00a0phagocytophilum\n                    <\/jats:italic>\n                    , polyclonal gammopathy with a monoclonal spike and moderate hypercalcemia were observed. There was marked hematuria, and\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\n                      taphylococcus aureus\n                    <\/jats:italic>\n                    was cultured from urine. Two weeks after successful treatment of the urinary tract infection, radiographs showed an extensive destructive monostotic lesion of the right humerus. Cytologic examination of fine\u2010needle aspirates of this lesion revealed a neoplastic round cell population suggestive of multiple myeloma. The dog was treated with melphalan and prednisolone for suspected multiple myeloma and doxycycline for suspected ehrlichiosis and anaplasmosis. Treatments lead to resolution of the clinical signs, hypercalcemia, and monoclonal gammopathy, and there was radiographic improvement of bone lesions; polyclonal gammopathy persisted. About one year after presentation the dog was still in clinical remission. This is a rare report of a dog with suspected multiple myeloma and a history of multiple chronic infectious diseases, suggesting that chronic infection and uncontrolled long\u2010term stimulation of the immune system could contribute to the pathogenesis of multiple myeloma.\n                  <\/jats:p>","DOI":"10.1111\/vcp.12018","type":"journal-article","created":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T15:20:10Z","timestamp":1357053610000},"page":"47-54","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Multiple myeloma in a dog with multiple concurrent infectious diseases and persistent polyclonal gammopathy"],"prefix":"10.1111","volume":"42","author":[{"given":"Caroline","family":"Geigy","sequence":"first","affiliation":[{"name":"Division of Radiation Oncology University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Riond","sequence":"additional","affiliation":[{"name":"Clinical Laboratory University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla Rohrer","family":"Bley","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Grest","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Pathology University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Kircher","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Imaging Vetsuisse Faculty University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Lutz","sequence":"additional","affiliation":[{"name":"Clinical Laboratory University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,31]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2008.00102.x"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04355.x"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-33-1-45"},{"key":"e_1_2_4_5_1","first-page":"2155","volume-title":"Cancer: Principles and Practice of Oncology","author":"Munshi JN","year":"2005"},{"key":"e_1_2_4_6_1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0889-8588(18)30348-4","article-title":"Diagnostic criteria of multiple myeloma","volume":"2","author":"Kyle RA","year":"1992","journal-title":"Hematol Oncol Clin North Am"},{"key":"e_1_2_4_7_1","first-page":"119","article-title":"Light\u2010chain myeloma in a dog","volume":"1","author":"Cowgill ES","year":"2004","journal-title":"J Vet Intern Med"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098588602300220"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21745"},{"key":"e_1_2_4_10_1","first-page":"1697","article-title":"Respiratory tract infections in the pathway to multiple myeloma: a population\u2010based study in Scandinavia","volume":"12","author":"Landgren O","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1991.172"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-121285"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1987.tb01980.x"},{"key":"e_1_2_4_14_1","first-page":"1302","article-title":"Use of plasmapheresis and chemotherapy for treatment of monoclonal gammopathy associated with Ehrlichia canis infection in a dog","volume":"10","author":"Matus RE","year":"1987","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1991.tb00947.x"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2005.tb00285.x"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.71.835"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(96)01013-8"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2008.05.003"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00268-08"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00379-10"},{"key":"e_1_2_4_22_1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1939-1676.2002.tb02374.x","article-title":"Consensus statement on ehrlichial disease of small animals from the infectious disease study group of the ACVIM","volume":"3","author":"Neer TM","year":"2002","journal-title":"J Vet Intern Med"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1996.tb02061.x"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01622-09"},{"key":"e_1_2_4_25_1","first-page":"698","volume-title":"Infectious Diseases of the Dog and Cat","author":"Baneth G","year":"2006"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(92)90055-E"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.61.1153"},{"key":"e_1_2_4_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(96)01152-1"},{"key":"e_1_2_4_29_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.11-0202"},{"key":"e_1_2_4_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756\u20103305\u20103\u201034"},{"key":"e_1_2_4_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2008.00080.x"},{"key":"e_1_2_4_32_1","first-page":"105","article-title":"Screening panels for monoclonal gammopathies: time to change","volume":"3","author":"Katzmann JA","year":"2009","journal-title":"Clin Biochem Rev"},{"key":"e_1_2_4_33_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.2002.01314.x"},{"key":"e_1_2_4_34_1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1939-1676.2005.tb02675.x","article-title":"Recognition and classification of dysmyelopoiesis in the dog: a review","volume":"2","author":"Weiss DJ","year":"2005","journal-title":"J Vet Intern Med"},{"key":"e_1_2_4_35_1","doi-asserted-by":"publisher","DOI":"10.3109\/02656739109034968"},{"key":"e_1_2_4_36_1","first-page":"699","volume-title":"Small Animal Clinical Oncology","author":"Vail M","year":"2007"},{"key":"e_1_2_4_37_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.40-1-32"},{"key":"e_1_2_4_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2427(99)00051-3"}],"container-title":["Veterinary Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvcp.12018","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vcp.12018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T22:52:23Z","timestamp":1700607143000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vcp.12018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,31]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1111\/vcp.12018"],"URL":"https:\/\/doi.org\/10.1111\/vcp.12018","archive":["Portico"],"relation":{},"ISSN":["0275-6382","1939-165X"],"issn-type":[{"value":"0275-6382","type":"print"},{"value":"1939-165X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,31]]},"assertion":[{"value":"2012-12-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}