{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:24:24Z","timestamp":1789453464646,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T00:00:00Z","timestamp":1394496000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Models for the regulation of thrombopoiesis predict that platelet mass is the biologically regulated variable, yet clinical evaluations of thrombopoiesis are often based on platelet number. When thrombocytopenia and variation in platelet size occur concurrently, platelet count may poorly estimate total platelet mass, confounding clinical decision making.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We hypothesized that plateletcrit (<jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content>) provides clinically important information when platelet number is an incomplete representation of platelet mass, such as in genetic macrothrombocytopenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively compared platelet count and<jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content>s with general reference intervals for 4 groups of dogs: sick Cavalier King Charles Spaniels (CKCS) and Greyhounds, presented for nonhematopoietic disease to the University of Minnesota (measured using an Advia 2120) and Auburn University Teaching Hospitals (measured using an Advia 120) over a 3\u2010year period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A canine<jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content>reference interval of 0.129\u20130.403% was established. None of the 4 sample groups had significantly more individuals below the reference interval for plateletcrit. For platelet count, only the 2 CKCS groups had significantly more individuals below the reference interval than predicted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Use of the<jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content>as determined by the Advia 120\/2120 appeared to avoid overestimation of low platelet mass in sick CKCS in a clinical setting. In contrast, the<jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content>performed similarly to the platelet count in evaluation of platelet mass in sick Greyhounds. Evaluation of the<jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content>should be considered in other conditions associated with increased mean platelet volume.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vcp.12116","type":"journal-article","created":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T15:36:15Z","timestamp":1390318575000},"page":"43-49","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Platelet count and plateletcrit in Cavalier King Charles Spaniels and Greyhounds using the Advia 120 and 2120"],"prefix":"10.1111","volume":"43","author":[{"given":"Jessica","family":"Kelley","sequence":"first","affiliation":[{"name":"Veterinary Clinical Sciences Department University of Minnesota St. Paul MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie C.","family":"Sharkey","sequence":"additional","affiliation":[{"name":"Veterinary Clinical Sciences Department University of Minnesota St. Paul MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pete W.","family":"Christopherson","sequence":"additional","affiliation":[{"name":"Department of Pathobiology Auburn University Auburn AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Rendahl","sequence":"additional","affiliation":[{"name":"School of Statistics University of Minnesota Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1492"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.135.12.281"},{"key":"e_1_2_5_4_1","doi-asserted-by":"crossref","first-page":"838","DOI":"10.2460\/javma.1994.205.06.838","article-title":"Platelet concentration and hemoglobin function in greyhounds","volume":"205","author":"Sullivan PS","year":"1994","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2008.00054.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2011.00360.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2008.0085.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2007.00319.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2012.00455.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1532\/LH96.04064"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2008.0061.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02253.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2011.653391"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03614.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2011.01396.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.1986.tb00651.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2001.219.1552"}],"updated-by":[{"DOI":"10.1111\/vcp.12205","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2014,10,24]],"date-time":"2014-10-24T00:00:00Z","timestamp":1414108800000}}],"container-title":["Veterinary Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvcp.12116","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vcp.12116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T12:06:51Z","timestamp":1716466011000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vcp.12116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/vcp.12116"],"URL":"https:\/\/doi.org\/10.1111\/vcp.12116","archive":["Portico"],"relation":{},"ISSN":["0275-6382","1939-165X"],"issn-type":[{"value":"0275-6382","type":"print"},{"value":"1939-165X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"2014-03-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}