{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:22:38Z","timestamp":1787016158095,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,10,8]],"date-time":"2014-10-08T00:00:00Z","timestamp":1412726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A 9\u2010year\u2010old female spayed English Springer Spaniel was evaluated for a cranial mediastinal mass and lymphocytosis. Flow cytometric immunophenotyping of peripheral blood lymphocytes revealed 97% as\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    3 positive, confirming a T\u2010cell lineage. Additionally, T\u2010cell subset assessment showed 53.2% to be double\u2010negative T\u2010lymphocytes, expressing neither\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    4 nor\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    8 surface markers. The number of double\u2010negative lymphocytes in circulation coincided with the number of T\u2010cell receptor (\n                    <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>\n                    ) \u03b3\u03b4\u2010expressing T\u2010cells in circulation. Molecular T\u2010cell clonality analysis of TCR Gamma (TCRG) gene rearrangement showed a polyclonal expansion of T\u2010lymphocytes. Histopathology confirmed the mass to be a thymoma, supporting the diagnosis of thymoma\u2010associated T\u2010cell lymphocytosis. Resolution of the lymphocytosis after removal of the thymoma provided further evidence for this diagnosis. To the authors' knowledge, this case is only the second report of thymoma\u2010associated peripheral lymphocytosis in the veterinary literature, and is the first to report a confirmed thymoma\u2010associated peripheral \u03b3\u03b4 T\u2010cell lymphocytosis in a dog.\n                  <\/jats:p>","DOI":"10.1111\/vcp.12196","type":"journal-article","created":{"date-parts":[[2014,10,8]],"date-time":"2014-10-08T10:08:43Z","timestamp":1412762923000},"page":"584-588","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Thymoma\u2010associated lymphocytosis in a dog"],"prefix":"10.1111","volume":"43","author":[{"given":"Andrew G.","family":"Burton","sequence":"first","affiliation":[{"name":"Veterinary Medical Teaching Hospital University of California\u2010Davis Davis CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dori L.","family":"Borjesson","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology University of California\u2010Davis Davis CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Vernau","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology University of California\u2010Davis Davis CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,8]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2427(99)00051-3"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.43-3-241"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2011.12.019"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19971015)80:8<1409::AID-CNCR7>3.0.CO;2-9"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000196666"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019606-199708000-00009"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197704)39:4<1455::AID-CNCR2820390417>3.0.CO;2-#"},{"key":"e_1_2_3_9_1","first-page":"279","article-title":"Malignant thymoma associated with T\u2010cell lymphocytosis: a case report with immunophenotypic and gene re\u2010arrangement analysis","volume":"117","author":"Medeiros LJ","year":"1993","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/102.4.447"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2010.00962.x"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2006.11.001"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.17.1.523"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2006.tb00716.x"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(78)90464-3"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60630-6"},{"key":"e_1_2_3_17_1","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.2460\/javma.1994.205.07.1007","article-title":"Thymoma in dogs: 23 cases (1980\u20101991)","volume":"205","author":"Atwater SW","year":"1994","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000341633"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10329"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05128.x"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141718"}],"container-title":["Veterinary Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvcp.12196","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vcp.12196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T12:23:40Z","timestamp":1717417420000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vcp.12196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,8]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/vcp.12196"],"URL":"https:\/\/doi.org\/10.1111\/vcp.12196","archive":["Portico"],"relation":{},"ISSN":["0275-6382","1939-165X"],"issn-type":[{"value":"0275-6382","type":"print"},{"value":"1939-165X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,8]]},"assertion":[{"value":"2014-10-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}