{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:21:05Z","timestamp":1787016065929,"version":"build-2736575974"},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,2,23]],"date-time":"2015-02-23T00:00:00Z","timestamp":1424649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2015,6]]},"abstract":"Abstract<\/jats:title>\n \n A 9.5\u2010year\u2010old, male castrated Walker Hound was presented for evaluation of progressive weakness, anorexia, and weight loss. Imaging revealed multiple abdominal and thoracic masses and ascites; fine\u2010needle aspirates of mesenteric and splenic masses confirmed malignancy, most likely histiocytic sarcoma. Laboratory analyses revealed increased ionized calcium and parathyroid hormone\u2010related peptide (\n PTH<\/jats:styled-content>\n \u2010\n rP<\/jats:styled-content>\n ) concentrations, and concurrent low\u2013normal parathyroid hormone concentration, consistent with humoral hypercalcemia of malignancy. Necropsy was performed after euthanasia. The dog had disseminated histiocytic sarcoma, including sarcomatosis, as well as bilateral thyroid carcinoma.\n PTH<\/jats:styled-content>\n \u2010\n rP<\/jats:styled-content>\n immunostaining was positive in the thyroid carcinoma but negative in the histiocytic neoplasm. These results suggest that thyroid carcinoma\u2010associated hypercalcemia can be caused by tumor secretion of\n PTH<\/jats:styled-content>\n \u2010\n rP<\/jats:styled-content>\n .\n <\/jats:p>","DOI":"10.1111\/vcp.12244","type":"journal-article","created":{"date-parts":[[2015,2,23]],"date-time":"2015-02-23T12:07:14Z","timestamp":1424693234000},"page":"249-252","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Hypercalcemia and parathyroid hormone\u2010related peptide expression in a dog with thyroid carcinoma and histiocytic sarcoma"],"prefix":"10.1111","volume":"44","author":[{"given":"Jennifer L.","family":"Scruggs","sequence":"first","affiliation":[{"name":"Department of Biomedical and Diagnostic Sciences College of Veterinary Medicine University of Tennessee Knoxville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Nobrega\u2010Lee","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Diagnostic Sciences College of Veterinary Medicine University of Tennessee Knoxville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael M.","family":"Fry","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Diagnostic Sciences College of Veterinary Medicine University of Tennessee Knoxville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rory","family":"Applegate","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences College of Veterinary Medicine University of Tennessee Knoxville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,23]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.131.3.1157"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.tcam.2012.09.003"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.5326\/0460020"},{"key":"e_1_2_4_5_1","first-page":"1101","article-title":"Paraneoplastic hypercalcemia in a dog with thyroid carcinoma","volume":"53","author":"Lane AE","year":"2012","journal-title":"Can Vet J"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.51.303"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098589403100303"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2013.09.012"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2008.00015.x"},{"key":"e_1_2_4_10_1","first-page":"188","article-title":"Differential diagnosis for hypercalcemia \u2013 A retrospective study of 46 dogs","volume":"140","author":"Uehlinger P","year":"1998","journal-title":"Schweiz Arch Tierheilkd"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01213369"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu5093605"}],"container-title":["Veterinary Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvcp.12244","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vcp.12244","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T13:58:38Z","timestamp":1696168718000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vcp.12244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,23]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1111\/vcp.12244"],"URL":"https:\/\/doi.org\/10.1111\/vcp.12244","archive":["Portico"],"relation":{},"ISSN":["0275-6382","1939-165X"],"issn-type":[{"value":"0275-6382","type":"print"},{"value":"1939-165X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,23]]},"assertion":[{"value":"2015-02-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}