{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:22:39Z","timestamp":1787016159743,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,5,4]],"date-time":"2015-05-04T00:00:00Z","timestamp":1430697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A 22\u2010year\u2010old Tennessee Walking Horse mare was presented to the Auburn University Large Animal Teaching Hospital with a 3\u2010day history of lethargy, anorexia, and mild signs of colic. The mare had a several\u2010month history of weight loss and refractory cough. Physical examination revealed an increased respiratory rate, and crackles and wheezes were heard on thoracic auscultation. Thoracic ultrasonographic examination showed disseminated, minor, bilateral comet tail\u2010like lesions on the parietal pleural surfaces. Abdominal ultrasonographic examination was unremarkable. Trans\u2010rectal palpation revealed a firm small colon impaction with concomitant diarrhea. Laboratory data were characterized by a very pronounced acute inflammatory leukogram with severe neutropenia and significant left shift, evidence of hepatocellular damage\/necrosis, cholestasis, and possibly mixed metabolic alkalosis and acidosis. On cytologic evaluation of a peritoneal fluid sample, there were many large granular lymphocytes (\n                    <jats:styled-content style=\"fixed-case\">LGL<\/jats:styled-content>\n                    ). Large numbers of\n                    <jats:styled-content style=\"fixed-case\">LGL<\/jats:styled-content>\n                    were also observed on cytologic examination of a subsequent transtracheal wash. The final cytologic interpretation was disseminated lymphoma with\n                    <jats:styled-content style=\"fixed-case\">LGL<\/jats:styled-content>\n                    morphology. Due to worsening of the clinical signs and poor prognosis, the mare was euthanized. On necropsy and in histopathologic examination, disseminated lymphoma with\n                    <jats:styled-content style=\"fixed-case\">LGL<\/jats:styled-content>\n                    morphology was noted in a mesenteric lymph node, lungs, liver, spleen, kidneys, and right dorsal colon. Lymphoma with\n                    <jats:styled-content style=\"fixed-case\">LGL<\/jats:styled-content>\n                    morphology is rarely diagnosed in the horse. This report provides unique cytologic findings of a case of disseminated lymphoma with\n                    <jats:styled-content style=\"fixed-case\">LGL<\/jats:styled-content>\n                    morphology in a horse, confirmed with histopathologic evaluation.\n                  <\/jats:p>","DOI":"10.1111\/vcp.12262","type":"journal-article","created":{"date-parts":[[2015,5,4]],"date-time":"2015-05-04T11:39:41Z","timestamp":1430739581000},"page":"437-441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Disseminated lymphoma with large granular lymphocyte morphology diagnosed in a horse via abdominal fluid and transtracheal wash cytology"],"prefix":"10.1111","volume":"44","author":[{"given":"Cinzia","family":"Mastrorilli","sequence":"first","affiliation":[{"name":"Department of Pathobiology College of Veterinary Medicine Auburn University Auburn AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Cesar","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine Auburn University Auburn AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kellye","family":"Joiner","sequence":"additional","affiliation":[{"name":"Department of Pathobiology College of Veterinary Medicine Auburn University Auburn AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne A.","family":"Wooldridge","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine Auburn University Auburn AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pete W.","family":"Christopherson","sequence":"additional","affiliation":[{"name":"Department of Pathobiology College of Veterinary Medicine Auburn University Auburn AL 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