{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:20:48Z","timestamp":1787016048284,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T00:00:00Z","timestamp":1431388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2015,9]]},"abstract":"Abstract<\/jats:title>\n \n A 2\u2010year and 6\u2010month\u2010old female neutered Labrador Retriever with Horner syndrome, megaesophagus, and a mediastinal mass was referred to the Queen Mother Hospital for Animals of the Royal Veterinary College. A large granular lymphocyte (\n LGL<\/jats:styled-content>\n ) lymphoma was diagnosed on cytology; flow cytometric analysis revealed a \u03b3\u03b4 T\u2010cell phenotype (\n CD<\/jats:styled-content>\n 3+,\n CD<\/jats:styled-content>\n 5+,\n CD<\/jats:styled-content>\n 45+,\n TCR<\/jats:styled-content>\n \u03b3\u03b4+,\n CD<\/jats:styled-content>\n 4\u2212,\n CD<\/jats:styled-content>\n 8\u2212,\n CD<\/jats:styled-content>\n 34\u2212,\n CD<\/jats:styled-content>\n 21\u2212). Chemotherapy was started with a combination of lomustine, vincristine, procarbazine, and prednisolone, followed by bleyomicin. Euthanasia was elected by the owners, due to progressive deterioration and lack of quality of life, 28\u00a0days after diagnosis. This is the first cytologic and immunophenotypic characterization of a canine \u03b3\u03b4 T\u2010cell lymphoma with\n LGL<\/jats:styled-content>\n morphology and probably of mediastinal origin. The role of chemotherapy in delaying the disease progression remains unknown.\n <\/jats:p>","DOI":"10.1111\/vcp.12265","type":"journal-article","created":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T08:29:24Z","timestamp":1431419364000},"page":"442-447","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Gamma delta T\u2010cell large granular lymphocyte lymphoma in a dog"],"prefix":"10.1111","volume":"44","author":[{"given":"Ana Liza","family":"Ortiz","sequence":"first","affiliation":[{"name":"University of Cambridge Veterinary School Trust Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Queen Mother Hospital for Animals Royal Veterinary College London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Leo","sequence":"additional","affiliation":[{"name":"Queen Mother Hospital for Animals Royal Veterinary College London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4814-2273","authenticated-orcid":false,"given":"Fulvio","family":"Riondato","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy","family":"Archer","sequence":"additional","affiliation":[{"name":"University of Cambridge Veterinary School Trust Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Cian","sequence":"additional","affiliation":[{"name":"Animal Health Trust Newmarket UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,12]]},"reference":[{"key":"e_1_2_3_2_1","first-page":"46","volume-title":"TNM Classification of Tumours in Domestic Animals","author":"Owen LN","year":"1980"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2007.09.018"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12111"},{"key":"e_1_2_3_5_1","unstructured":"BatschinskiK.Combination of Bleomycin and Cytosine Arabinoside Chemotherapy for Relapsed Canine Lymphoma.Proceedings of the Veterinary Cancer Society Meeting Albuquerque New Mexico November 4\u20137 2011."},{"key":"e_1_2_3_6_1","first-page":"608","volume-title":"Withrow & MacEwen's Small Animal Clinical Oncology","author":"Vail DM","year":"2013"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985813478210"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2004.04.002"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2005.02.020"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/104063870501700404"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2010.03.011"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.37-6-637"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1309\/LRKX8CE7GVPCR1FT"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985812451625"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.40-5-556"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2004.12.002"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000086659"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2013.03.006"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2008.05.009"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2009.169"},{"key":"e_1_2_3_21_1","first-page":"411","article-title":"Gamma\/delta T\u2010cell lymphoma in a dog","volume":"50","author":"Borska P","year":"2009","journal-title":"Can Vet J"},{"key":"e_1_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2008.00048.x"},{"key":"e_1_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1993.tb01021.x"},{"key":"e_1_2_3_24_1","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.2460\/javma.1994.205.12.1722","article-title":"Prognostic factors for treatment of malignant lymphoma in dogs","volume":"205","author":"Teske E","year":"1994","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_3_25_1","first-page":"807","article-title":"Assessment of potential doubling time (Tpot), argyrophilic nucleolar organizer regions (AgNOR),\u00a0and proliferating cell nuclear antigen (PCNA) as predictors of therapy response in canine non\u2010Hodgkin's lymphoma","volume":"24","author":"Vail DM","year":"1996","journal-title":"Exp Hematol"}],"container-title":["Veterinary Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvcp.12265","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vcp.12265","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T19:01:50Z","timestamp":1717873310000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vcp.12265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,12]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/vcp.12265"],"URL":"https:\/\/doi.org\/10.1111\/vcp.12265","archive":["Portico"],"relation":{},"ISSN":["0275-6382","1939-165X"],"issn-type":[{"value":"0275-6382","type":"print"},{"value":"1939-165X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,12]]},"assertion":[{"value":"2015-05-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}