{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:54:51Z","timestamp":1770220491260,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T00:00:00Z","timestamp":1431561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2015,9]]},"abstract":"Background<\/jats:title>N\u2010terminal pro\u2010B\u2010type natriuretic peptide (NT<\/jats:styled-content>\u2010proBNP<\/jats:styled-content>) is a cardiac biomarker whose plasma concentration is high in some dogs with cardiopulmonary disease. NT<\/jats:styled-content>\u2010proBNP<\/jats:styled-content> is a diagnostic tool that can be used to help determine if a patient has congestive heart failure. Greyhounds have functional heart murmurs, relative cardiomegaly, and high serum cTnI<\/jats:styled-content> concentration.<\/jats:p><\/jats:sec>Objectives<\/jats:title>The purpose of the study was to evaluate the plasma concentration of NT<\/jats:styled-content>\u2010proBNP<\/jats:styled-content> in healthy Greyhounds and compare it to non\u2010Greyhound dogs.<\/jats:p><\/jats:sec>Methods<\/jats:title>We prospectively evaluated healthy client\u2010owned dogs including retired racing Greyhounds and non\u2010Greyhounds. Plasma was obtained and transferred into tubes containing a protease inhibitor and submitted for a specific NT<\/jats:styled-content>\u2010proBNP ELISA<\/jats:styled-content> assay.<\/jats:p><\/jats:sec>Results<\/jats:title>The plasma NT<\/jats:styled-content>\u2010proBNP<\/jats:styled-content> concentration in Greyhounds was significantly higher than in non\u2010Greyhound control dogs (946 vs 632\u00a0pmol\/L; P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.005); 46% of Greyhounds had NT<\/jats:styled-content>\u2010proBNP<\/jats:styled-content> >\u00a01000\u00a0pmol\/L.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Plasma NT<\/jats:styled-content>\u2010proBNP<\/jats:styled-content> concentration in Greyhounds is high and should be interpreted with caution.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vcp.12266","type":"journal-article","created":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T14:05:58Z","timestamp":1431612358000},"page":"405-409","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Plasma N\u2010terminal pro\u2010B\u2010type natriuretic peptide concentration in healthy retired racing Greyhounds"],"prefix":"10.1111","volume":"44","author":[{"given":"Kristen M.","family":"Couto","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences The Ohio State University Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Cristina","family":"Iazbik","sequence":"additional","affiliation":[{"name":"The Ohio State University Veterinary Medical Center Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana M.","family":"Mar\u00edn","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences The Ohio State University Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Zaldivar\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences The Ohio State University Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa J.","family":"Beal","sequence":"additional","affiliation":[{"name":"IDEXX Laboratories Westbrook ME USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"G\u00f3mez Ochoa","sequence":"additional","affiliation":[{"name":"Vetoclock Telemedicine Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Guillermo","family":"Couto","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences The Ohio State University Columbus OH USA"},{"name":"The Ohio State University College of Veterinary Medicine and Comprehensive Cancer Center Columbus OH USA"},{"name":"Vetoclock Telemedicine Zaragoza Spain"},{"name":"Couto Veterinary Consultants Hilliard OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,14]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2011.00360.x"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2011.00383.x"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.107869"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.243.1.71"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.10.081"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S5789"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.240.2.171"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.72.5.642"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2013.07.010"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.68.1.42"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2007.00510.x"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2010.03.004"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12310"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2013.07.025"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2007.00252.x"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2008.0237.x"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2006.tb02826.x"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-011-9249-z"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2009.0373.x"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2006.tb02894.x"},{"key":"e_1_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-013-0889-z"},{"key":"e_1_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.020420"}],"container-title":["Veterinary Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvcp.12266","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vcp.12266","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T12:27:52Z","timestamp":1696163272000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vcp.12266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,14]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/vcp.12266"],"URL":"https:\/\/doi.org\/10.1111\/vcp.12266","archive":["Portico"],"relation":{},"ISSN":["0275-6382","1939-165X"],"issn-type":[{"value":"0275-6382","type":"print"},{"value":"1939-165X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,14]]},"assertion":[{"value":"2015-05-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}