{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T14:13:45Z","timestamp":1783952025426,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,11,27]],"date-time":"2015-11-27T00:00:00Z","timestamp":1448582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001343","name":"University of Pretoria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001343","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2015,12]]},"abstract":"Background<\/jats:title>Thrombocytopenia without clinical bleeding is a consistent finding in virulent canine babesiosis.<\/jats:p><\/jats:sec>Objectives<\/jats:title>The purpose of the study was to investigate the platelet index phenotype in Babesia rossi<\/jats:italic>\u2010infected dogs and the association with disease outcome. We hypothesized that an increased proportion of large, activated platelets would be present.<\/jats:p><\/jats:sec>Methods<\/jats:title>Ninety\u2010six infected and 15 control dogs were included. Babesia<\/jats:italic>\u2010infected dogs were further divided into survivors and nonsurvivors. Platelet count, mean platelet volume (MPV<\/jats:styled-content>), platelet volume distribution width (PDW<\/jats:styled-content>), plateletcrit (PCT<\/jats:styled-content>), mean platelet mass (MPM<\/jats:styled-content>), mean platelet component concentration (MPC<\/jats:styled-content>), and platelet component distribution width (PCDW<\/jats:styled-content>) were measured at presentation, and at 24 and 48\u00a0hours in admitted survivors.<\/jats:p><\/jats:sec>Results<\/jats:title>Mortality rate was 13% (12\/96). At presentation, compared to controls, PLT<\/jats:styled-content> and PCT<\/jats:styled-content> were significantly decreased in survivors and nonsurvivors (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.001 for both). Mean platelet volume was significantly increased in survivors and nonsurvivors compared to the controls (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.001 for both); however, MPM<\/jats:styled-content> was only significantly increased in the survivors (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.001). There were no differences between the survivors and nonsurvivors for any of the indices at presentation. Platelet count and PCT<\/jats:styled-content> were significantly increased at 24 and 48\u00a0hours, and MPC<\/jats:styled-content> significantly increased at 24\u00a0hours for admitted survivors compared to the values at presentation.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Large, activated platelets were significantly increased and may play a role in the lack of a bleeding phenotype, despite severe thrombocytopenia, in canine babesiosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vcp.12306","type":"journal-article","created":{"date-parts":[[2015,11,27]],"date-time":"2015-11-27T15:42:39Z","timestamp":1448638959000},"page":"493-497","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Platelet indices in dogs with Babesia rossi<\/i> infection"],"prefix":"10.1111","volume":"44","author":[{"given":"Amelia","family":"Goddard","sequence":"first","affiliation":[{"name":"Department of Companion Animal Clinical Studies Faculty of Veterinary Science University of Pretoria Pretoria South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L.","family":"Leisewitz","sequence":"additional","affiliation":[{"name":"Department of Companion Animal Clinical Studies Faculty of Veterinary Science University of Pretoria Pretoria South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie T.","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical and Animal Sciences Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan P.","family":"Schoeman","sequence":"additional","affiliation":[{"name":"Department of Companion Animal Clinical Studies Faculty of Veterinary Science University of Pretoria Pretoria South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,27]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.4102\/jsava.v80i2.177"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.4102\/jsava.v74i3.512"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2006.11.008"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200205001-00022"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2012.09.009"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2007.77.943"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2015.05.008"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2007.00904.x"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2010.00224.x"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0320(19991015)38:5<250::AID-CYTO8>3.0.CO;2-K"},{"key":"e_1_2_4_12_1","first-page":"95","article-title":"Number of thrombocytes and mean platelet volume in canine babesiosis","volume":"156","author":"Rafaj RB","year":"2005","journal-title":"Rev M\u00e9d V\u00e9t"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2007.tb00201.x"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/095371002220148332"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2008.04.012"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12405"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2005.66.325"}],"container-title":["Veterinary Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvcp.12306","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vcp.12306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T09:45:30Z","timestamp":1695548730000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vcp.12306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,27]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1111\/vcp.12306"],"URL":"https:\/\/doi.org\/10.1111\/vcp.12306","archive":["Portico"],"relation":{},"ISSN":["0275-6382","1939-165X"],"issn-type":[{"value":"0275-6382","type":"print"},{"value":"1939-165X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,27]]},"assertion":[{"value":"2015-11-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}