{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T03:00:24Z","timestamp":1769914824264,"version":"3.49.0"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,28]],"date-time":"2015-12-28T00:00:00Z","timestamp":1451260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2016,3]]},"abstract":"Abstract<\/jats:title>A 7\u2010year\u2010old male Boxer with a 3.5\u2010year history of atopy and food hypersensitivity was presented with multiple poorly circumscribed nodules and maculae of the skin and tongue, and jaundiced mucosal membranes. Cytologic and histopathologic examination of the skin lesions revealed cutaneous epitheliotropic lymphoma. Cells were CD<\/jats:styled-content>3+<\/jats:sup> and CD<\/jats:styled-content>8+<\/jats:sup> in flow cytometry. The CBC<\/jats:styled-content> showed a moderate leukocytosis with 16% atypical lymphocytes with irregularly cleaved nuclei. Flow cytometric phenotyping of peripheral blood showed an elevated proportion of the CD<\/jats:styled-content>8+<\/jats:sup> T\u2010lymphocyte subpopulation, indicating a malignant population of T\u2010cell origin, and the electropherogram of the PCR<\/jats:styled-content> antigen receptor rearrangement produced a monoclonal peak for TCR<\/jats:styled-content>\u03b3. Liver enzyme activities were markedly increased and abdominal ultrasound examination showed increased echogenicity of the liver and enlarged abdominal lymph nodes. Fine\u2010needle aspirates of the liver confirmed infiltration with lymphocytes exhibiting the same morphology as the cells detected in skin and peripheral blood. Treatment was induced with L\u2010asparaginase, lomustine, and prednisone. Partial clinical remission of the skin and tongue lesions was achieved within 10\u00a0days, and hematologic abnormalities resolved. Despite further treatment with L\u2010asparaginase and lomustine, the dog relapsed within one\u00a0month and was euthanized. Presence of malignant lymphocytes in skin, peripheral blood, and liver indicate a rare variant of leukemic cutaneous T\u2010cell lymphoma, equivalent of S\u00e9zary syndrome in a dog. This case report describes the use of flow cytometry as a complementary tool for lymphocyte characterization of skin lesions for the first time.<\/jats:p>","DOI":"10.1111\/vcp.12311","type":"journal-article","created":{"date-parts":[[2015,12,28]],"date-time":"2015-12-28T15:34:42Z","timestamp":1451316882000},"page":"172-178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Cutaneous T\u2010cell lymphoma \u2013 S\u00e9zary syndrome in a Boxer"],"prefix":"10.1111","volume":"45","author":[{"given":"Barbara C.","family":"R\u00fctgen","sequence":"first","affiliation":[{"name":"Clinical Pathology Department of Pathobiology University of Veterinary Medicine Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Flickinger","sequence":"additional","affiliation":[{"name":"Clinic for Internal Medicine Department for Small Animals and Horses University of Veterinary Medicine Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitt","family":"Wolfesberger","sequence":"additional","affiliation":[{"name":"Clinic for Internal Medicine Department for Small Animals and Horses University of Veterinary Medicine Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Litschauer","sequence":"additional","affiliation":[{"name":"Clinic for Internal Medicine Department for Small Animals and Horses University of Veterinary Medicine Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Fuchs\u2010Baumgartinger","sequence":"additional","affiliation":[{"name":"Department of Pathobiology Institute of Pathology University of Veterinary Medicine Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine E.","family":"Hammer","sequence":"additional","affiliation":[{"name":"Department of Pathobiology 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