{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T20:42:00Z","timestamp":1771620120184,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,23]],"date-time":"2016-01-23T00:00:00Z","timestamp":1453507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Cardiac troponin I (<jats:styled-content style=\"fixed-case\">cTnI<\/jats:styled-content>) is a peripheral blood marker for myocardial damage. Because of the unavailability of goat\u2010specific <jats:styled-content style=\"fixed-case\">cTnI<\/jats:styled-content> assays human <jats:styled-content style=\"fixed-case\">cTnI<\/jats:styled-content> assays may be validated for detection of myocarditis in goat kids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The purpose of the study was to evaluate 2 commercially available human <jats:styled-content style=\"fixed-case\">cTnI<\/jats:styled-content> assays in goat kids with myocardial damage, and to determine the <jats:styled-content style=\"fixed-case\">cTnI<\/jats:styled-content> expression in cardiac muscle.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Plasma <jats:styled-content style=\"fixed-case\">cTnI<\/jats:styled-content> concentrations were measured in healthy goat kids (<jats:italic>n<\/jats:italic> = 7) and goat kids with myocardial damage (<jats:italic>n<\/jats:italic> = 8) using the Beckman Coulter Access Accu TnI and the Biom\u00e9rieux Vidas Ultra. The results were correlated with gross necropsy and histopathologic findings, and <jats:styled-content style=\"fixed-case\">cTnI<\/jats:styled-content> immunhistochemistry in cardiac tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Macro\u2010 and microscopic findings confirmed myocardial damage in the myocarditis group. Mean plasma <jats:styled-content style=\"fixed-case\">cTnI<\/jats:styled-content> concentration was significantly higher in the myocarditis group than in the healthy control group (104.82 vs 0.02 ng\/mL). The overall mean plasma <jats:styled-content style=\"fixed-case\">cTnI<\/jats:styled-content> concentration measured by Biom\u00e9rieux Vidas Ultra (61.75 ng\/mL, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 19.55\u2013103.95) was comparable to the mean measured by Beckman Coulter Access Accu TnI (50.08 ng\/mL, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 24.11\u201376.06), and <jats:styled-content style=\"fixed-case\">cTnI<\/jats:styled-content> concentrations measured by these assays were highly correlated (<jats:italic>r<\/jats:italic> = .977) with a \u22126.2% bias. Both assays were precise and accurate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The human\u2010specific Beckman Coulter Access Accu TnI and the Biom\u00e9rieux Vidas Ultra can be used for diagnostic confirmation of myocardial damage in caprine medicine.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vcp.12328","type":"journal-article","created":{"date-parts":[[2016,1,23]],"date-time":"2016-01-23T21:36:37Z","timestamp":1453584997000},"page":"164-171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The diagnostic value of two commercially available human <scp>cTnI<\/scp> assays in goat kids with myocarditis"],"prefix":"10.1111","volume":"45","author":[{"given":"Tolga","family":"Karapinar","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Faculty of Veterinary Medicine Firat University Elazig Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yesari","family":"Eroksuz","sequence":"additional","affiliation":[{"name":"Department of Pathology Veterinary Faculty Firat University Elazig Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armagan","family":"Hayirli","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Nutritional Disorders Faculty of Veterinary Medicine Ataturk University Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enver","family":"Beytut","sequence":"additional","affiliation":[{"name":"Department of Pathology Veterinary Faculty Kafkas University Kars Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozgur","family":"Kaynar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Veterinary Medicine Ataturk University Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ersoy","family":"Baydar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Faculty of Veterinary Medicine Firat University Elazig Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Sozdutmaz","sequence":"additional","affiliation":[{"name":"Department of Virology Faculty of Veterinary Medicine Erciyes University Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakan","family":"Isidan","sequence":"additional","affiliation":[{"name":"Department of Virology Faculty of Veterinary Medicine Cumhuriyet University Sivas Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,23]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-4679(02)00463-8"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2008.00307.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2007.03.017"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2011.165795"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1093\/clinchem\/45.7.1018","article-title":"Degradation of cardiac troponin I in serum complicates comparisons of cardiac troponin I assays","volume":"45","author":"Shi Q","year":"1999","journal-title":"Clin Chem"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655101300133667"},{"key":"e_1_2_5_8_1","first-page":"110","article-title":"Comparison of the analytical performance for measurement of cardiac troponin I","volume":"22","author":"Chien TI","year":"2012","journal-title":"J Biomed Lab Sci"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2003.tb02464.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2009.0355.x"},{"key":"e_1_2_5_11_1","first-page":"397","article-title":"High cardiac troponin I plasma concentration in a calf with myocarditis","volume":"51","author":"Karapinar T","year":"2010","journal-title":"Can Vet J"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2012.00448.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvc.2011.08.002"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.74.6.870"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.71.1.55"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2009.0256.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2012.06.013"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/75.6.816"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1974.10480196"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2006.tb00131.x"},{"key":"e_1_2_5_21_1","first-page":"709","article-title":"A new biometrical procedure for testing the equality of measurements from two different analytical methods. Application of linear regression procedures for method comparison studies in Clinical Chemistry, Part I","volume":"21","author":"Passing H","year":"1983","journal-title":"J Clin Chem Clin Biochem"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/096228029900800204"},{"key":"e_1_2_5_23_1","first-page":"443","volume-title":"Large Animal Internal Medicine","author":"Reef VB","year":"2002"},{"key":"e_1_2_5_24_1","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S0735-1097(00)00804-4","article-title":"Myocardial infarction redefined a consensus document of the Joint European Society of Cardiology\/American College of Cardiology committee for the redefinition of myocardial infarction","volume":"36","author":"Alpert JS","year":"2000","journal-title":"J Am College Cardiol"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/00313020120062947"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2005.07.011"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2007.12.006"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2012.00953.x"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2000.217.231"},{"key":"e_1_2_5_30_1","first-page":"356","article-title":"Cardiac isoenzymes in healthy Holstein calves and calves with experimentally induced endotoxemia","volume":"72","author":"Peek SF","year":"2008","journal-title":"Can J Vet Res"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2001.tb01582.x"},{"key":"e_1_2_5_32_1","first-page":"869","article-title":"Cardiac troponin I release correlates with myocardial infarction size","volume":"33","author":"Mair J","year":"1995","journal-title":"Eur J Clin Chem Clin Biochem"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/110.2.241"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2006.tb00712.x"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/0192623308322016"},{"key":"e_1_2_5_36_1","unstructured":"HyTest Ltd.Troponins. Markers of Cardiovascular Diseases and Metabolic Syndrome. Available at:www.hytest.fi. Accessed June 2013."},{"key":"e_1_2_5_37_1","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1093\/clinchem\/43.8.1379","article-title":"Troponin I is released in bloodstream of patients with acute myocardial infarction not in free form but as complex","volume":"43","author":"Katrukha AG","year":"1997","journal-title":"Clin Chem"},{"key":"e_1_2_5_38_1","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1093\/clinchem\/44.6.1198","article-title":"Characterization of cardiac troponin subunit release into serum after acute myocardial infarction and comparison of assays for troponin T and I. American Association for Clinical Chemistry Subcommittee on cTnI Standardization","volume":"44","author":"Wu Ah","year":"1998","journal-title":"Clin Chem"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1258\/acb.2007.007229"}],"container-title":["Veterinary Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvcp.12328","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vcp.12328","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T08:04:53Z","timestamp":1694937893000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vcp.12328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,23]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/vcp.12328"],"URL":"https:\/\/doi.org\/10.1111\/vcp.12328","archive":["Portico"],"relation":{},"ISSN":["0275-6382","1939-165X"],"issn-type":[{"value":"0275-6382","type":"print"},{"value":"1939-165X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,23]]},"assertion":[{"value":"2016-01-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}