{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T14:34:55Z","timestamp":1717684495117},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,3,7]],"date-time":"2016-03-07T00:00:00Z","timestamp":1457308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 12\u2010year\u2010old, male castrated Domestic Shorthair cat was presented to Animal Medical Center of Gifu Univeristy with anorexia and vomiting. Physical examination revealed an enlarged left tonsil and right mandibular lymph node (approximately 2\u20133\u00d7 the normal size), and a submucosal mass on the right side of the epiglottis (1.5\u00a0\u00d7\u00a02.0\u00a0cm). On computed tomography images, an enlarged left tonsil, and enlarged right mandibular, right pharyngeal, and left and right cervical lymph nodes were observed. Cytologic examination of smears of tonsil and lymph nodes revealed numerous medium\u2010 to large\u2010sized neoplastic lymphoid cells, approximately half of which contained one or several light\u2010blue homogenous globoid cytoplasmic inclusions (5\u201310\u00a0\u03bcm), which stained magenta with periodic acid\u2013Schiff (<jats:styled-content style=\"fixed-case\">PAS<\/jats:styled-content>) stain. Histopathologic examination of the left tonsil revealed diffuse proliferation of medium\u2010 to large\u2010sized neoplastic lymphoid cells effacing the original lymphoid architecture. Half of the cells contained one or several eosinophilic globoid cytoplasmic inclusions, which stained magenta with <jats:styled-content style=\"fixed-case\">PAS<\/jats:styled-content> and showed positive immunohistochemical reactions for immunoglobulin M (IgM) and \u03bb light chain. Neoplastic lymphoid cells were also <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>20<jats:sup>+<\/jats:sup>, Pax5<jats:sup>+<\/jats:sup>, and <jats:styled-content style=\"fixed-case\">MUM<\/jats:styled-content>1<jats:sup>+<\/jats:sup>, and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>3<jats:sup>\u2212<\/jats:sup>. Thus, the neoplastic lymphoid cells expressed a B\u2010cell immunophenotype, and the globoid cytoplasmic inclusions represented an aberrant IgM \u03bb light chain accumulation, similar to Russell bodies. B\u2010cell lymphoma with Mott cell differentiation was diagnosed based on cytologic, histopathologic, and immunohistochemical features. This is the first report of B\u2010cell lymphoma with Mott cell differentiation in a cat.<\/jats:p>","DOI":"10.1111\/vcp.12343","type":"journal-article","created":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T04:22:44Z","timestamp":1457410964000},"page":"356-360","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["B\u2010cell lymphoma with Mott cell differentiation in a cat"],"prefix":"10.1111","volume":"45","author":[{"given":"Tomomi","family":"Kanehara","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Pathology Gifu University Gifu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Matsui","sequence":"additional","affiliation":[{"name":"Animal Medical Center Gifu University Gifu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mami","family":"Murakami","sequence":"additional","affiliation":[{"name":"Animal Medical Center Gifu 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