{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:05:37Z","timestamp":1791165937306,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T00:00:00Z","timestamp":1475539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Erroneously high reticulocyte counts (pseudoreticulocytosis) have been reported in dogs with leukemia. Pseudoreticulocytosis and an abnormal reticulocyte profile were observed in a dog with large form babesiosis presented at our institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aims of this retrospective study were to determine if dogs with babesiosis and other dogs had abnormal reticulocyte profiles, and to correlate these profiles with the primary diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All canine <jats:styled-content style=\"fixed-case\">CBC<\/jats:styled-content>s obtained with the Sysmex <jats:styled-content style=\"fixed-case\">XT<\/jats:styled-content>\u20102000iV or Procyte <jats:styled-content style=\"fixed-case\">DX<\/jats:styled-content> were reviewed. Cases of large form babesiosis were identified and their reticulocyte dot plots were analyzed. Dogs with abnormal reticulocyte profiles but without microscopically apparent intraerythrocytic <jats:italic>Babesia<\/jats:italic> piroplasms were identified. The reticulocyte profiles and fluorescence ratios of dogs with and without babesiosis were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty of 92 dogs with babesiosis had abnormal reticulocyte profiles, including 8 with a separation between the reticulocyte and mature <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> plots or a continuum of reticulocytes from the <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> plot but with a higher density of dots in the middle of the \u201ccomet tail\u201d than in the left quarter of the dot plot. Thirteen of 6980 dogs without <jats:italic>Babesia<\/jats:italic> on the blood smear had abnormal reticulocyte profiles, including 3 with leukemia. The medium\u2010fluorescence reticulocyte ratios tended to be higher in dogs with babesiosis and abnormal dot plots than in other dogs, whereas the high\u2010fluorescence ratio was higher in one dog with leukemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Abnormal reticulocyte dot plots and atypical reticulocyte fluorescence ratios may occur in dogs with babesiosis and alert clinical pathologists to consider this diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vcp.12396","type":"journal-article","created":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T15:18:11Z","timestamp":1476285491000},"page":"598-603","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Spurious reticulocyte profiles in dogs with large form babesiosis: a retrospective study"],"prefix":"10.1111","volume":"45","author":[{"given":"Laetitia","family":"Piane","sequence":"first","affiliation":[{"name":"Equipe de Biologie M\u00e9dicale\u2010Histologie CREFRE Universit\u00e9 de Toulouse INSERM UPS ENVT Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen M.","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Pathobiological Sciences School of Veterinary Medicine University of Wisconsin\u2010Madison Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Giraud","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de M\u00e9decine Interne Universit\u00e9 de Toulouse UPS INP ENVT Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Bourges\u2010Abella","sequence":"additional","affiliation":[{"name":"Equipe de Biologie M\u00e9dicale\u2010Histologie CREFRE Universit\u00e9 de Toulouse INSERM UPS ENVT Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Trumel","sequence":"additional","affiliation":[{"name":"Equipe de Biologie M\u00e9dicale\u2010Histologie CREFRE Universit\u00e9 de Toulouse INSERM UPS ENVT Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2010.08.001"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2257.1999.00243.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199712253372615"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.12.4729-4731.2002"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-007-0314-6"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2011.00322.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2012.32.6.392"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.2006.00871.x"},{"key":"e_1_2_5_10_1","first-page":"125","article-title":"Reticulocyte counting by flow cytometry. 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