{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T17:30:05Z","timestamp":1744306205896},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T00:00:00Z","timestamp":1476748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Dirofilaria repens<\/jats:italic> is a parasitic nematode in the subcutaneous tissue of carnivores, including dogs and cats, transmitted by mosquitoes. Human beings may be accidental hosts. Infection of a dog with <jats:italic>D repens<\/jats:italic> was first reported in Palestine in 1934, and 2 additional cases were reported in dogs in Israel to date. This report describes <jats:italic>D repens<\/jats:italic> infection in 4 dogs in Israel that presented with subcutaneous masses, which were cytologically characterized by marked mast cell and eosinophil infiltration. In 3 cases, multiple microfilariae were present in the lesions; rare microfilariae were present in the 4<jats:sup>th<\/jats:sup> case. In all 4 dogs, <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> of fine\u2010needle aspirates from the lesions were positive for <jats:italic>D repens<\/jats:italic>. The mast cells observed in all lesions were uniform and highly granulated, and with the presence of the microfilariae, a mast cell tumor was considered less likely. This report suggests that <jats:italic>D repens<\/jats:italic> infection\u2010associated subcutaneous lesions, characterized cytologically by massive mast cell and eosinophil infiltration, should be considered a differential diagnosis for mast cell tumor, especially in geographic locations endemic for this nematode. Notably, all 4 dogs were infected with <jats:italic>D repens<\/jats:italic> despite a routine prophylactic doramectin therapy administered every 3 months, probably due to the relatively long time interval between treatments.<\/jats:p>","DOI":"10.1111\/vcp.12410","type":"journal-article","created":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T16:26:48Z","timestamp":1476808008000},"page":"703-709","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Marked subcutaneous mast cell and eosinophilic infiltration associated with the presence of multiple <i>Dirofilaria repens<\/i> microfilariae in 4 dogs"],"prefix":"10.1111","volume":"45","author":[{"given":"Michal","family":"Mazaki\u2010Tovi","sequence":"first","affiliation":[{"name":"Koret School of Veterinary Medicine Hebrew University of Jerusalem Rehovot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Reich","sequence":"additional","affiliation":[{"name":"Ramat Hasharon Veterinary Center Ramat Hasharon Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adva","family":"Karnieli","sequence":"additional","affiliation":[{"name":"Karnieli Vet Ltd. Molecular Veterinary Diagnosis Tivon Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Kuzi","sequence":"additional","affiliation":[{"name":"Koret School of Veterinary Medicine Hebrew University of Jerusalem Rehovot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itamar","family":"Aroch","sequence":"additional","affiliation":[{"name":"Koret School of Veterinary Medicine Hebrew University of Jerusalem Rehovot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,18]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2005.10.013"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00012-12"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2014.02.008"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.66.1087"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01590-12"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2009.03.026"},{"key":"e_1_2_3_8_1","first-page":"232","article-title":"Parasitic worms of dogs and cats in Palestine","volume":"14","author":"Witenberg G","year":"1934","journal-title":"Vet Rec"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(02)00006-7"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1999.61.639"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199509000-00014"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.1999.00301.x"},{"key":"e_1_2_3_13_1","first-page":"208","article-title":"Human ocular dirofilariasis in Israel","volume":"12","author":"Romano A","year":"1976","journal-title":"Isr J Med Sci"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(81)80201-8"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2009.00212.x"},{"key":"e_1_2_3_16_1","first-page":"217","article-title":"A mini\u2010invasive procedure for removal of adult Dirofilaria repens from subcutaneous nodules in dogs","volume":"9","author":"Luigi V","year":"2011","journal-title":"Int J Appl Res Vet Med"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1998.tb03715.x"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12009"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/578385"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3164.2002.00305.x"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20181"},{"key":"e_1_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-010-2028-2"},{"key":"e_1_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2005.10.002"},{"key":"e_1_2_3_24_1","first-page":"67","article-title":"Efficacy of ivermectin in preventing Dirofilaria repens infestation in dogs naturally exposed to contagion","volume":"35","author":"Marconcini A","year":"1993","journal-title":"Parassitologia"},{"key":"e_1_2_3_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-011-2404-6"},{"key":"e_1_2_3_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2010.01.034"}],"container-title":["Veterinary Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvcp.12410","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvcp.12410","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vcp.12410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T03:53:30Z","timestamp":1696046010000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vcp.12410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,18]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1111\/vcp.12410"],"URL":"https:\/\/doi.org\/10.1111\/vcp.12410","archive":["Portico"],"relation":{},"ISSN":["0275-6382","1939-165X"],"issn-type":[{"value":"0275-6382","type":"print"},{"value":"1939-165X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,18]]},"assertion":[{"value":"2016-10-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}