{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:47:52Z","timestamp":1740149272387,"version":"3.37.3"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T00:00:00Z","timestamp":1479686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 10\u2010year\u2010old castrated Domestic Short\u2010Haired cat was presented to a primary care veterinarian for a wellness examination and laboratory examination for monitoring of diabetes mellitus. The <jats:styled-content style=\"fixed-case\">CBC<\/jats:styled-content> revealed marked thrombocytosis, leukopenia and macrocytic, normochromic anemia. The cat tested negative for Fe<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> and feline immunodeficiency virus, but was positive for <jats:italic>Mycoplasma haemominutum<\/jats:italic> by <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>. Hematologic abnormalities were not responsive to therapy, so a repeat <jats:styled-content style=\"fixed-case\">CBC<\/jats:styled-content> and a bone marrow aspiration for cytology were performed. Additional blood smear findings included anisocytosis with megaloblastic erythroid precursors, large platelets, eosinophilic myelocytes and metamyelocytes, and rare unidentified blasts. The bone marrow smear was highly cellular, and the cytologic pattern was consistent with myelodysplastic syndrome with an erythroid predominance. At that time, 15% blasts were present. The cat was treated with a vitamin K<jats:sub>2<\/jats:sub> analog, doxycycline, and prednisolone, but without a clinical response. Within 3 months, euthanasia was elected due to declining quality of life, and a necropsy was performed. Postmortem bone marrow smears were highly cellular and dominated by monomorphic blasts of unknown line of origin (52%), persistent marked erythroid and megakaryocytic dysplasia, and ineffective erythropoiesis and granulopoiesis. Immunohistochemical, immunocytochemical, and cytochemical stains resulted in a diagnosis of acute myeloid leukemia of unclassified type. Additional histologic findings included mixed hepatitis with trematode infestation and lymphoplasmacytic interstitial nephritis with fibrosis. The marked thrombocytosis with myelodysplastic syndrome and the Fe<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>\u2010negative status of this cat were unusual. The difficulty in classifying the myelodysplasia and subsequent leukemia highlights a need for further reporting and characterization of these types of disease.<\/jats:p>","DOI":"10.1111\/vcp.12426","type":"journal-article","created":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T15:04:45Z","timestamp":1479740685000},"page":"584-593","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Suspected myelodysplastic\/myeloproliferative neoplasm in a feline leukemia virus\u2010negative cat"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3481-5393","authenticated-orcid":false,"given":"Amy L.","family":"Weeden","sequence":"first","affiliation":[{"name":"Department of Physiological Sciences College of Veterinary Medicine University of Florida Gainesville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle 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