{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T06:52:47Z","timestamp":1785653567039,"version":"3.56.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T00:00:00Z","timestamp":1486080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"\u201cJuan de la Cierva\u201d of \u2018Ministerio de Economia y Competitividad\u2019, Spain"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The measurement of acute phase proteins (<jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content>) is being increasingly used in human and veterinary medicine in diagnosis, prognosis, treatment monitoring, and in general health screening. However, information about the <jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content> response in cats infected with agents of vector\u2010borne diseases is lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The purpose of the study was to investigate the concentrations of serum amyloid A (<jats:styled-content style=\"fixed-case\">SAA<\/jats:styled-content>), haptoglobin (Hp), and paraoxonase\u20101 (<jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content>1) in cats naturally infected with <jats:italic>Hepatozoon felis<\/jats:italic> and <jats:italic>Babesia vogeli<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum concentrations of <jats:styled-content style=\"fixed-case\">SAA<\/jats:styled-content>, Hp, and <jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content>1 were determined in 19 cats naturally infected with <jats:italic>H felis<\/jats:italic> and in 11 cats naturally infected with <jats:italic>B vogeli<\/jats:italic>, and compared to concentrations in 10 healthy control cats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum Hp concentrations were significantly increased, and <jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content>1 concentrations significantly decreased in symptomatic and asymptomatic cats infected with <jats:italic>H felis<\/jats:italic> and <jats:italic>B vogeli<\/jats:italic> when compared with healthy noninfected cats. In the <jats:italic>H felis<\/jats:italic>\u2010infected population, concentrations of <jats:styled-content style=\"fixed-case\">SAA<\/jats:styled-content> and Hp were significantly increased in symptomatic cats when compared with asymptomatic animals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrated differences in <jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content> concentrations in cats infected with <jats:italic>H felis<\/jats:italic> and <jats:italic>B vogeli<\/jats:italic>. Therefore, Hp and <jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content>1 concentrations could be helpful in discriminating healthy cats from cats with asymptomatic or symptomatic infection by these agents.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vcp.12451","type":"journal-article","created":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T21:52:16Z","timestamp":1486158736000},"page":"72-76","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Acute phase proteins response in cats naturally infected with <i>Hepatozoon felis<\/i> and <i>Babesia vogeli<\/i>"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3976-1619","authenticated-orcid":false,"given":"Hugo","family":"Vilhena","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine Vasco da Gama Universitary School Coimbra Portugal"},{"name":"Baixo Vouga Veterinary Hospital \u00c1gueda Portugal"},{"name":"Animal and Veterinary Research Centre (CECAV) Tr\u00e1s\u2010os\u2010Montes and Alto Douro University Vila Real Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asta","family":"Tvarijonaviciute","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery Autonomous University of Barcelona Barcelona Spain"},{"name":"Interdisciplinary Laboratory of Clinical Analysis Interlab\u2010UMU University of Murcia Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 J","family":"Cer\u00f3n","sequence":"additional","affiliation":[{"name":"Interdisciplinary Laboratory of Clinical Analysis Interlab\u2010UMU University of Murcia Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisete","family":"Vieira","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences Tr\u00e1s\u2010os\u2010Montes and Alto Douro University Vila Real Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Pastor","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery Autonomous University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana C","family":"Silvestre\u2010Ferreira","sequence":"additional","affiliation":[{"name":"Animal and Veterinary Research Centre (CECAV) Tr\u00e1s\u2010os\u2010Montes and Alto Douro University Vila Real Portugal"},{"name":"Department of Veterinary Sciences Tr\u00e1s\u2010os\u2010Montes and Alto Douro University Vila Real Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,3]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2010.04.009"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2007.12.001"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118359"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2015.02.007"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2009.00493.x"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-6-102"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-6-99"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X13480985"},{"key":"e_1_2_4_10_1","first-page":"1","article-title":"Seroprevalence of heartworm (Dirofilaria immitis) in feline and canine hosts from central and northern Portugal","volume":"14","author":"Vieira L","year":"2014","journal-title":"J Helminthol"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(98)00160-5"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11259-006-3373-6"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.domaniend.2011.10.003"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2005.04.017"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2014.05.002"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2011.12.009"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1040638713486112"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2014.01.023"}],"container-title":["Veterinary Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvcp.12451","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vcp.12451","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vcp.12451","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vcp.12451","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T13:49:26Z","timestamp":1694180966000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vcp.12451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,3]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1111\/vcp.12451"],"URL":"https:\/\/doi.org\/10.1111\/vcp.12451","archive":["Portico"],"relation":{},"ISSN":["0275-6382","1939-165X"],"issn-type":[{"value":"0275-6382","type":"print"},{"value":"1939-165X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,3]]},"assertion":[{"value":"2017-02-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}