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Clinicopathologic and imaging abnormalities included anemia, azotemia, icterus, and hepatomegaly with hypoechoic masses. On cytologic evaluation of a fine\u2010needle aspiration of a liver mass there was abundant extracellular pink\u2010 to purple\u2010colored material between hepatocytes. The amorphous material was stained with direct fast scarlet (<jats:styled-content style=\"fixed-case\">DFS<\/jats:styled-content>), and green birefringent areas were observed under polarized light, confirming the presence of amyloid. A unique finding on the cytologic smear were macrophages containing amorphous and fibrillar amyloid\u2010like protein. Histopathologic examination using H&amp;E and Congo red staining confirmed amyloid deposits within the space of Disse, along the sinusoids, portal tracts, blood vessel walls, and within the cytoplasm of macrophages. Immunohistochemical staining with anti\u2010<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> amyloid antibodies further confirmed the presence of <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> amyloid. To the author's knowledge, this is the first report of the cytologic finding of <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> amyloid protein within macrophages and <jats:styled-content style=\"fixed-case\">DFS<\/jats:styled-content> stain detection of amyloid on a cytologic smear.<\/jats:p>","DOI":"10.1111\/vcp.12486","type":"journal-article","created":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T16:44:06Z","timestamp":1495125846000},"page":"331-336","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Hepatic <scp>AA<\/scp> amyloidosis in a cat: cytologic and histologic identification of <scp>AA<\/scp> amyloid in macrophages"],"prefix":"10.1111","volume":"46","author":[{"given":"Sakurako","family":"Neo\u2010suzuki","sequence":"first","affiliation":[{"name":"Laboratory of Small Animal Internal Medicine School of Veterinary Medicine Azabu University Sagamihara 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