{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T16:23:49Z","timestamp":1771518229016,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T00:00:00Z","timestamp":1494892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"IDEXX Laboratories, Portland, ME, USA"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Reticulocyte hemoglobin content (<jats:styled-content style=\"fixed-case\">RET<\/jats:styled-content>\u2010H<jats:italic>e<\/jats:italic>) is a diagnostic marker for iron deficiency (<jats:styled-content style=\"fixed-case\">ID<\/jats:styled-content>) in people and dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of our study was to evaluate the clinical utility of <jats:styled-content style=\"fixed-case\">RET<\/jats:styled-content>\u2010H<jats:italic>e<\/jats:italic> in the diagnosis of different causes of iron\u2010deficient erythropoiesis (IDE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Canine <jats:styled-content style=\"fixed-case\">CBC<\/jats:styled-content>s were separated into 2 groups according to <jats:styled-content style=\"fixed-case\">RET<\/jats:styled-content>\u2010H<jats:italic>e<\/jats:italic> values, &lt;\u00a020.9\u00a0pg or \u2265\u00a020.9\u00a0pg. Erythrocyte and reticulocyte variables were compared between dogs with decreased and normal <jats:styled-content style=\"fixed-case\">RET<\/jats:styled-content>\u2010H<jats:italic>e<\/jats:italic> values. Additional data for a subgroup of dogs were collected, and dogs with low <jats:styled-content style=\"fixed-case\">RET<\/jats:styled-content>\u2010H<jats:italic>e<\/jats:italic> values were categorized as having ID, inflammatory disorders (<jats:styled-content style=\"fixed-case\">INFL<\/jats:styled-content>), portosystemic shunt (<jats:styled-content style=\"fixed-case\">PSS<\/jats:styled-content>), miscellaneous diseases (<jats:styled-content style=\"fixed-case\">MISC<\/jats:styled-content>), or combinations of these diseases (<jats:styled-content style=\"fixed-case\">ID<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">INFL<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> ID<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">PSS<\/jats:styled-content>). Hematologic variables were compared between dogs of the different disease groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 10.3% (1084\/10,553) of canine <jats:styled-content style=\"fixed-case\">CBC<\/jats:styled-content>s showed decreased <jats:styled-content style=\"fixed-case\">RET<\/jats:styled-content>\u2010H<jats:italic>e<\/jats:italic> values. Significant differences between dogs with decreased and normal <jats:styled-content style=\"fixed-case\">RET<\/jats:styled-content>\u2010H<jats:italic>e<\/jats:italic> values were found for all erythrocyte and reticulocyte variables. The majority (68.9%, 747\/1084) of dogs with low <jats:styled-content style=\"fixed-case\">RET<\/jats:styled-content>\u2010H<jats:italic>e<\/jats:italic> values was anemic; 28.9% (216\/747) of those anemic dogs had microcytosis and hypochromasia. In the subgroup of dogs, 8.9% (205\/2306) had low <jats:styled-content style=\"fixed-case\">RET<\/jats:styled-content>\u2010H<jats:italic>e<\/jats:italic> values. According to their diagnosed diseases, anemic dogs (138\/205) could be categorized as <jats:styled-content style=\"fixed-case\">ID<\/jats:styled-content> (17\/138; 12.3%), <jats:styled-content style=\"fixed-case\">INFL<\/jats:styled-content> (16\/138; 11.6%), <jats:styled-content style=\"fixed-case\">PSS<\/jats:styled-content> (30\/138; 21.7%), <jats:styled-content style=\"fixed-case\">ID<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">INFL<\/jats:styled-content> (63\/138; 45.7%), <jats:styled-content style=\"fixed-case\">ID<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">PSS<\/jats:styled-content> (8\/138; 5.8%), and <jats:styled-content style=\"fixed-case\">MISC<\/jats:styled-content> (4\/138; 2.9%). Distribution in nonanemic dogs (67\/205) was similar, except for a lower number of dogs with <jats:styled-content style=\"fixed-case\">PSS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Low <jats:styled-content style=\"fixed-case\">RET<\/jats:styled-content>\u2010H<jats:italic>e<\/jats:italic> values indicate IDE even in dogs with other <jats:styled-content style=\"fixed-case\">CBC<\/jats:styled-content> variables within the <jats:styled-content style=\"fixed-case\">RI<\/jats:styled-content>s.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vcp.12499","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T13:23:21Z","timestamp":1494941001000},"page":"422-429","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Canine reticulocyte hemoglobin content (<scp>RET<\/scp>\u2010H<i>e<\/i>) in different types of iron\u2010deficient erythropoiesis"],"prefix":"10.1111","volume":"46","author":[{"given":"Jannika","family":"Fuchs","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Clinical Pathology and Clinical Pathophysiology Justus\u2010Liebig\u2010University Giessen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Moritz","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Clinical Pathology and Clinical Pathophysiology Justus\u2010Liebig\u2010University Giessen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Gru\u00dfendorf","sequence":"additional","affiliation":[{"name":"Small Animal Clinic Gru\u00dfendorf Bramsche Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Lechner","sequence":"additional","affiliation":[{"name":"Small Animal Clinic N\u00fcrnberg\u2010Hafen N\u00fcrnberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Neuerer","sequence":"additional","affiliation":[{"name":"Small Animal Clinic Ismaning Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Nickel","sequence":"additional","affiliation":[{"name":"Small Animal Clinic Norderstedt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Rieker","sequence":"additional","affiliation":[{"name":"AniCura Small Animal Specialists Ravensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Schwedes","sequence":"additional","affiliation":[{"name":"AniCura Small Animal Specialists Augsburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis B.","family":"DeNicola","sequence":"additional","affiliation":[{"name":"IDEXX Laboratories Portland ME USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Russell","sequence":"additional","affiliation":[{"name":"IDEXX Laboratories Portland ME USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natali","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Clinical Pathology and Clinical Pathophysiology Justus\u2010Liebig\u2010University Giessen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2006.tb00110.x"},{"key":"e_1_2_7_3_1","first-page":"167","volume-title":"Schalm's Veterinary Hematology","author":"Weiss DJ","year":"2010"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2005.tb00004.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e32835f5933"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12311"},{"key":"e_1_2_7_7_1","first-page":"136","volume-title":"Schalm's Veterinary Hematology","author":"Christian JA","year":"2010"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2009.01160.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2013.07.002"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2010.292"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1385\/MO:23:1:23"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12219"},{"key":"e_1_2_7_13_1","first-page":"256","article-title":"New red cell parameters on the Sysmex XE\u20102100 (TM) as potential markers of functional iron deficiency","volume":"28","author":"Briggs C","year":"2001","journal-title":"Infusionsther Transfusionsmed"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.2006.00812.x"},{"key":"e_1_2_7_15_1","unstructured":"FuchsJ MoritzA BauerN et\u00a0al.Multicenterstudie zur Messung des H\u00e4moglobingehalts der Retikulozyten am H\u00e4matologieger\u00e4t ProCyte Dx beim Hund: 61st annual DVG Vet Congress \u2010 Abstracts accepted for presentation;2015."},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfu038"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2009.01215.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2015.01.008"},{"key":"e_1_2_7_19_1","first-page":"246","volume-title":"Schalm's Veterinary Hematology","author":"Fry MM","year":"2010"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12340"},{"key":"e_1_2_7_21_1","first-page":"E8","article-title":"Reticulocyte hemoglobin content (CHr) does not differentiate true from functional iron deficency in dogs: American Society for Veterinary Clinical Pathology (ASVCP) 49th Annual Meeting \u2010 Scientific Abstracts","volume":"43","author":"Radakovich LB","year":"2014","journal-title":"Vet Clin Pathol"},{"key":"e_1_2_7_22_1","volume-title":"Veterinary Hematology: A Diagnostic Guide and Color Atlas","author":"Harvey JW","year":"2012"},{"key":"e_1_2_7_23_1","first-page":"36","volume-title":"Schalm's Veterinary Hematology","author":"Olver CS","year":"2010"}],"container-title":["Veterinary Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvcp.12499","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vcp.12499","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T08:10:15Z","timestamp":1695543015000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vcp.12499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,16]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/vcp.12499"],"URL":"https:\/\/doi.org\/10.1111\/vcp.12499","archive":["Portico"],"relation":{},"ISSN":["0275-6382","1939-165X"],"issn-type":[{"value":"0275-6382","type":"print"},{"value":"1939-165X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,16]]},"assertion":[{"value":"2017-05-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}