{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:23:56Z","timestamp":1787016236450,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T00:00:00Z","timestamp":1496620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A 10\u2010year\u2010old crossbred dog was presented with a 6\u2010week history of hematemesis, melena, anorexia, and lethargy. Clinical evaluation revealed a gastric mass with a regional lymphadenomegaly as well as a monoclonal gammopathy manifesting as hyperglobulinemia. Cytologic and histopathologic analyses were consistent with a round cell neoplasm; neoplastic cells showed nuclear immunoreactivity for\n                    <jats:styled-content style=\"fixed-case\">MUM<\/jats:styled-content>\n                    1 and diffuse cytoplasmic reactivity for\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    3. Polymerase chain reactions performed on fixed and fresh tissue identified a clonal rearrangement with an IgH primer set. An extramedullary plasmacytoma (\n                    <jats:styled-content style=\"fixed-case\">EMP<\/jats:styled-content>\n                    ) was confirmed by cellular morphology and molecular diagnostics. Following an objective response to chemotherapy, the dog was euthanized 8\u00a0months after diagnosis, and a postmortem examination confirmed the clinical findings. This is the first reported case of a monoclonal gammopathy secondary to a gastric\n                    <jats:styled-content style=\"fixed-case\">EMP<\/jats:styled-content>\n                    coupled with aberrant expression of\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    3 in an aggressive plasmacytic tumor, and highlights the utility of molecular diagnostics for classifying atypical hemolymphoid neoplasms.\n                  <\/jats:p>","DOI":"10.1111\/vcp.12503","type":"journal-article","created":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T12:02:42Z","timestamp":1496664162000},"page":"520-525","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["A metastatic secretory gastric plasmacytoma with aberrant\n                    <scp>CD<\/scp>\n                    3 expression in a dog"],"prefix":"10.1111","volume":"46","author":[{"given":"Matthew J.","family":"Atherton","sequence":"first","affiliation":[{"name":"Department of Pathology and Molecular Medicine McMaster Immunology Research Centre McMaster University Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Vazquez\u2010Sanmartin","sequence":"additional","affiliation":[{"name":"Oncology Unit Animal Health Trust Newmarket UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Sharpe","sequence":"additional","affiliation":[{"name":"Diagnostic Services Unit Faculty of Veterinary Medicine University of Calgary Calgary AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elspeth M.","family":"Waugh","sequence":"additional","affiliation":[{"name":"College of Medical, Veterinary and Life Sciences University of Glasgow Scotland UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna S.","family":"Morris","sequence":"additional","affiliation":[{"name":"College 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