{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:24:23Z","timestamp":1770747863634,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T00:00:00Z","timestamp":1496620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 10\u2010year\u2010old, male neutered Shetland Sheepdog was presented to the University of Florida for evaluation of a well\u2010granulated mast cell tumor. Hydroxyurea therapy was instituted and serial <jats:styled-content style=\"fixed-case\">CBC<\/jats:styled-content>s showed persistent mild anemia and macrocytosis without a corresponding increase in polychromasia. The dog's <jats:styled-content style=\"fixed-case\">MCV<\/jats:styled-content> increased progressively, reaching its highest value of 100.0 <jats:styled-content style=\"fixed-case\">fL<\/jats:styled-content> after 6 months of treatment, and a diagnosis of macrocytosis associated with hydroxyurea therapy was made. The dog's increase in <jats:styled-content style=\"fixed-case\">MCV<\/jats:styled-content> was prominent, and rapidly decreased after the drug was discontinued, consistent with previous observations in human and canine subjects treated with hydroxyurea. Hydroxyurea is a cytotoxic chemotherapeutic agent used in a variety of conditions in human and veterinary medicine, and megaloblastic changes associated with its use have been described in multiple species. This report shows that hydroxyurea treatment is a differential diagnosis for prominent macrocytosis in dogs in the absence of other signs of erythrocyte regeneration.<\/jats:p>","DOI":"10.1111\/vcp.12511","type":"journal-article","created":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T16:02:49Z","timestamp":1496678569000},"page":"451-456","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Macrocytosis secondary to hydroxyurea therapy"],"prefix":"10.1111","volume":"46","author":[{"given":"Francisco O.","family":"Conrado","sequence":"first","affiliation":[{"name":"Department of Physiological Sciences College of Veterinary Medicine University of Florida Gainesville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy L.","family":"Weeden","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences College of Veterinary Medicine University of Florida Gainesville FL 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