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Clinical evaluation revealed ulcerating lesions on the gingiva and hard palate and a hematoma on the tongue. Computed tomography of the head and endoscopic examination of the esophagus and stomach were unremarkable. Hematology and clinical chemistry revealed severe nonregenerative anemia, mild thrombocytopenia, and moderate azotemia. Several<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>s for feline hemotropic mycoplasmas (<jats:italic>Mycoplasma\u00a0haemofelis, M\u00a0heamominutium, M\u00a0turicensis<\/jats:italic>),<jats:italic>Babesia felis<\/jats:italic>, and<jats:italic>Bartonella<\/jats:italic>spp., as well as an Fe<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>antigen test were negative. The cytologic examination of a bone marrow aspirate was consistent with ineffective erythropoiesis, most likely due to immune\u2010mediated destruction of the erythroid precursor cells. Prednisolone therapy was initiated (1.25\u00a0mg\/kg\/day), and the<jats:styled-content style=\"fixed-case\">CBC<\/jats:styled-content>returned to normal 16\u00a0days after the initiation of the therapy. Anemia relapsed after 4\u00a0months and severe splenomegaly was noted. A repeat bone marrow aspirate revealed active erythropoiesis in the presence of erythroid precursor phagocytosis suggesting an immune\u2010mediated process. Splenic fine\u2010needle aspiration and tissue biopsies were taken, and all findings including histology and immunohistochemistry were consistent with a diffuse large B\u2010cell lymphoma (DLBCL). Five days later, the clinical condition deteriorated and the jaguar died. Histopathology following necropsy showed infiltration with neoplastic lymphoblasts in the spleen, liver, and abdominal lymph nodes. This case report describes a nonregenerative immune\u2010mediated anemia associated with a DLBCL in a jaguar.<\/jats:p>","DOI":"10.1111\/vcp.12542","type":"journal-article","created":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T17:52:42Z","timestamp":1505325162000},"page":"597-604","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Nonregenerative immune\u2010mediated anemia associated with a diffuse large B\u2010cell lymphoma in a captive jaguar (<i>Panthera onca<\/i>)"],"prefix":"10.1111","volume":"46","author":[{"given":"Monika A.","family":"Keresztes","sequence":"first","affiliation":[{"name":"Clinical Pathophysiology and Clinical Pathology Department of Veterinary Clinical Sciences Justus\u2010Liebig\u2010University Gie\u00dfen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Henrich","sequence":"additional","affiliation":[{"name":"Institute of Veterinary 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