{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T01:50:30Z","timestamp":1783993830436,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T00:00:00Z","timestamp":1517875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 4\u2010year\u2010old Irish Setter was presented with a history of progressive left pelvic limb lameness. Orthopedic examination revealed pain on manipulation of the left stifle. Radiographs showed an osteolytic lesion in the subchondral bone of the medial tibial condyle. Fine\u2010needle aspirates were taken, and cytology revealed numerous cohesive clusters of plump, oval to spindloid cells often with perivascular distribution and moderate cellular atypia. A diagnosis of sarcoma was made with synovial cell sarcoma (<jats:styled-content style=\"fixed-case\">SCS<\/jats:styled-content>) and histiocytic sarcoma being the 2 main differentials. Histopathology confirmed the diagnosis of sarcoma and provided the same differentials. All neoplastic cells were positive for vimentin, and approximately 5% of them also stained with pan\u2010cytokeratin using immunohistochemical staining methods. Neoplastic cells did not express<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>18. The combination of this immunohistochemical profile and cell morphology was consistent with an<jats:styled-content style=\"fixed-case\">SCS<\/jats:styled-content>. Synovial cell sarcoma is a rare and poorly understood canine tumor entity. This is the first extensive description of the cytologic features of this neoplasm. The literature was also reviewed, focusing on comparative aspects of dogs and people, with a special emphasis on the cell of origin and diagnostic tools. Controversies regarding the nomenclature of this tumor are also presented. The authors propose a new term (cytokeratin\u2010positive joint\u2010associated sarcoma) for addressing this neoplasm until the cell of origin of this tumor is elucidated.<\/jats:p>","DOI":"10.1111\/vcp.12590","type":"journal-article","created":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T15:50:37Z","timestamp":1517932237000},"page":"181-185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Synovial cell sarcoma in a dog: A misnomer\u2014Cytologic and histologic findings and review of the literature"],"prefix":"10.1111","volume":"47","author":[{"given":"Paola","family":"Monti","sequence":"first","affiliation":[{"name":"Dick White Referrals DWR Diagnostics Cambridgeshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren","family":"Barnes","sequence":"additional","affiliation":[{"name":"Dick White Referrals DWR Diagnostics Cambridgeshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.","family":"Adrian","sequence":"additional","affiliation":[{"name":"Dick White Referrals DWR Diagnostics Cambridgeshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Rasotto","sequence":"additional","affiliation":[{"name":"Dick White Referrals DWR Diagnostics Cambridgeshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,6]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.2460\/javma.1994.205.09.1300","article-title":"Evaluation of prognostic factors for dogs with synovial sarcoma: 36 cases (1986\u20101991)","volume":"205","author":"Vail DM","year":"1994","journal-title":"J Am Vety Med Assoc"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.39-1-66"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.5326\/0380347"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213330.71745.39"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181b7ed36"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199801153380303"},{"key":"e_1_2_3_8_1","first-page":"786083","article-title":"A challenging case of metastatic intra\u2010abdominal synovial sarcoma with unusual immunophenotype and its differential diagnosis","volume":"2012","author":"Changchien YC","year":"2012","journal-title":"Case Rep Pathol"},{"key":"e_1_2_3_9_1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3941\/jrcr.v9i7.1977","article-title":"Primary synovial sarcoma of the abdominal wall: a case report and literature review","volume":"9","author":"Kritsaneepaiboon S","year":"2015","journal-title":"J Radiol Case Rep"},{"key":"e_1_2_3_10_1","first-page":"159","volume-title":"Jubb, Kennedy, Palmer's Pathology of Domestic Animals","author":"Craig LE","year":"2016"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(87)90102-2"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2013.11.206"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP45SSNAOPXYXU"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.01.032"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200211000-00005"},{"key":"e_1_2_3_16_1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.4142\/jvs.2004.5.2.173","article-title":"Canine biphasic synovial sarcoma: case report and immunohistochemical characterization","volume":"5","author":"Loukopoulos P","year":"2004","journal-title":"J Vet Sci"}],"container-title":["Veterinary Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvcp.12590","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vcp.12590","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:34:07Z","timestamp":1719794047000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vcp.12590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,6]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/vcp.12590"],"URL":"https:\/\/doi.org\/10.1111\/vcp.12590","archive":["Portico"],"relation":{},"ISSN":["0275-6382","1939-165X"],"issn-type":[{"value":"0275-6382","type":"print"},{"value":"1939-165X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,6]]},"assertion":[{"value":"2018-02-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}