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Proteomics was used to explore protein alterations in the presence of a hypothesized red blood cell membrane protein deficiency. Proteomic analysis revealed downregulation of the band 3, and alpha\u2010 and beta\u2010adducin proteins, and alterations in the red blood cell proteome consistent with previous reports of changes due to the presence of reticulocytosis and ongoing hemolysis. The spectrum of protein alterations identified in the affected dog may be homologous to a band 3 protein deficiency secondary to hereditary spherocytosis, as described in people.<\/jats:p>","DOI":"10.1111\/vcp.12627","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T15:21:33Z","timestamp":1532013693000},"page":"377-385","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Assessment of the red blood cell proteome in a dog with unexplained hemolytic anemia"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8486-8127","authenticated-orcid":false,"given":"Victoria L.","family":"Black","sequence":"first","affiliation":[{"name":"Bristol Veterinary School University of Bristol Langford Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Heesom","sequence":"additional","affiliation":[{"name":"School of Biochemistry 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