{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:20:50Z","timestamp":1787016050739,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T00:00:00Z","timestamp":1537315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2018,12]]},"abstract":"Abstract<\/jats:title>\n \n A 9\u2010year\u2010old spayed female Curly Coated Retriever was referred for evaluation of generalized peripheral lymphadenomegaly. The dog was clinically healthy on presentation with no anomalies detected on complete blood count, serum biochemistry, urinalysis, or three\u2010view thoracic radiographs. Fine\u2010needle aspiration (\n FNA<\/jats:styled-content>\n ) and cytology of the peripheral lymph nodes were consistent with lymphoma with an intermediate\u2010sized lymphoid population. Flow cytometry of peripheral lymph nodes was consistent with a homogeneous population of\n CD<\/jats:styled-content>\n 4\n +<\/jats:sup>\n T cells that had lost expression of the pan\u2010leukocyte antigen\n CD<\/jats:styled-content>\n 45. Variable expression of\n CD<\/jats:styled-content>\n 21,\n CD<\/jats:styled-content>\n 25, and class\n II<\/jats:styled-content>\n major histocompatibility complex (\n MHC<\/jats:styled-content>\n ) were also noted. This was considered consistent with T\u2010zone lymphoma (\n TZL<\/jats:styled-content>\n ), although the T cells were noted to be larger than usual based on flow cytometry. Due to the suspected indolent nature of this patient's disease and clinical progression, a careful monitoring approach was initially discussed with the owner. However, additional diagnostic testing was performed to confirm the diagnosis. Bone marrow cytology did not show any significant anomalies. The largest lymph node (left mandibular) was extirpated and submitted for histopathology. Based on the lymph node architecture, cellular features, and high mitotic activity, an unexpected diagnosis of peripheral T\u2010cell lymphoma not otherwise specified (\n PTCL<\/jats:styled-content>\n \u2010\n NOS<\/jats:styled-content>\n ) was made. The dog was started on\n CHOP<\/jats:styled-content>\n (cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy. This case illustrates the limitations of using flow cytometry as the sole means of diagnosing\n TZL<\/jats:styled-content>\n and highlights the importance of using complementary tests when subtyping canine lymphoma, which is significant when considering a patient's treatment plan and prognosis.\n <\/jats:p>","DOI":"10.1111\/vcp.12657","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T06:15:50Z","timestamp":1537337750000},"page":"643-648","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A case of canine high\u2010grade T\u2010cell lymphoma immunophenotypically consistent with T\u2010zone lymphoma"],"prefix":"10.1111","volume":"47","author":[{"given":"Cyril","family":"Parachini\u2010Winter","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine Oregon State University Corvallis Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlin M.","family":"Curran","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine Oregon State University Corvallis Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duncan S.","family":"Russell","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences College of Veterinary Medicine Oregon State University Corvallis Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Gorman","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences College of Veterinary Medicine Oregon State University Corvallis Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810379428"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2009.00200.x"},{"key":"e_1_2_5_4_1","first-page":"608","volume-title":"Withrow&MacEwen's Small Animal Clinical Oncology","author":"Vail DM","year":"2013"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2011.00317.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12048"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12155"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.15-0688"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.43-3-241"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985813478210"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12343"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12304"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12331"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12322"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12043"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2017.03.006"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2014.12.033"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2000.9l040.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1182\/blood.V79.4.1011.bloodjournal7941011","article-title":"Lack of CD45 antigen on blast cells in childhood acute lymphoblastic leukemia is associated with chromosomal hyperdiploidy and other favorable prognostic features [see comments]","volume":"79","author":"Behm F","year":"1992","journal-title":"Blood"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.10003"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2015.10.004"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12111"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12343"}],"container-title":["Veterinary Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvcp.12657","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vcp.12657","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T00:41:21Z","timestamp":1694738481000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vcp.12657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,19]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1111\/vcp.12657"],"URL":"https:\/\/doi.org\/10.1111\/vcp.12657","archive":["Portico"],"relation":{},"ISSN":["0275-6382","1939-165X"],"issn-type":[{"value":"0275-6382","type":"print"},{"value":"1939-165X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,19]]},"assertion":[{"value":"2017-11-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}