{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:42:44Z","timestamp":1770745364784,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T00:00:00Z","timestamp":1539820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Several breeds have physiological peculiarities that induce variations in reference intervals (RIs) compared with the general canine population. Shetland sheepdogs (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>s) are reported to be more predisposed to different diseases (eg, hyperlipidemia, gallbladder mucocele, and hypothyroidism). Consequently, a breed\u2010specific approach is more often required.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to determine whether the <jats:styled-content style=\"fixed-case\">RI<\/jats:styled-content>s of the general canine population could be applied to that of <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>s, and to generate breed\u2010specific <jats:styled-content style=\"fixed-case\">RI<\/jats:styled-content>s, where appropriate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u00a0clinically healthy and fasted <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>s (36% of the population registered at the Italian Breed association) were examined. Routine hematology and biochemistry analyses were performed. The transference method was used to compare the results of <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>s with the <jats:styled-content style=\"fixed-case\">RI<\/jats:styled-content>s of the general canine population. When these <jats:styled-content style=\"fixed-case\">RI<\/jats:styled-content>s were not validated, new <jats:styled-content style=\"fixed-case\">RI<\/jats:styled-content>s were generated according to the guidelines of the American Society of Veterinary Clinical Pathology. Differences associated with sex, age, coat color, and whether used as a pet, a herding dog, or an agility dog were also investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The transference method validated for 30\/38 <jats:styled-content style=\"fixed-case\">SS RI<\/jats:styled-content>s. For 6 of the remaining 8 variables, the difference with the claimed <jats:styled-content style=\"fixed-case\">RI<\/jats:styled-content>s could depend on preanalytical or analytical artifacts, whereas for glucose and total cholesterol, these differences could depend on breed peculiarities. However, in all <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>s, the concentration of cholesterol was &lt;12.95\u00a0mmol\/L. Relevant differences associated with sex, age, coat color, and use were not found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study suggests that breed\u2010specific <jats:styled-content style=\"fixed-case\">RI<\/jats:styled-content>s should be used for glucose and cholesterol in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>s.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vcp.12665","type":"journal-article","created":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T14:03:22Z","timestamp":1539871402000},"page":"617-624","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hematologic and biochemical reference intervals in Shetland Sheepdogs"],"prefix":"10.1111","volume":"47","author":[{"given":"Beatrice","family":"Ruggerone","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine University of Milan Milan Italy"},{"name":"Veterinary Teaching Hospital University of Milan Lodi Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Giraldi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine University of Milan Milan Italy"},{"name":"Veterinary Teaching Hospital University of Milan Lodi Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7117-7987","authenticated-orcid":false,"given":"Saverio","family":"Paltrinieri","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine University of Milan Milan Italy"},{"name":"Veterinary Teaching Hospital University of Milan Lodi Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Scarpa","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine University of Milan Milan Italy"},{"name":"Veterinary Teaching Hospital University of Milan Lodi Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,18]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"F\u00e9deration Cynologique Internationale.Fci\u2010Standard N\u00b0 88 \u2013 Shetland Sheepdog.http:\/\/www.fci.be\/nomenclature\/standards\/088g01-en.pdf. 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