{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T16:19:41Z","timestamp":1773332381659,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T00:00:00Z","timestamp":1553817600000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Companion Animal Clinical Studies of the University of Pretoria"},{"name":"South African National Research Foundation"},{"name":"IDEXX Laboratories (Pty) Ltd"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Dogs with <jats:italic>Babesia rossi<\/jats:italic> infection display a normocoagulable thromboelastogram, despite being markedly thrombocytopenic, which is purportedly due to large\u2010scale platelet activation. Thromboelastographic platelet mapping (TEG\u2010PM) evaluates individual contributions of thrombin, fibrinogen, and platelets to clot formation, and may elucidate some of the pathomechanisms of thrombocytopenia\u2010associated hemostatic alterations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study investigated potential differences in TEG\u2010PM variables in dogs with complicated <jats:italic>B\u00a0rossi <\/jats:italic>infection compared with healthy controls, and whether these variables correlated with platelet activation indices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The maximum amplitude (MA) following thrombin generation (MA<jats:sub>Thrombin<\/jats:sub>) was determined using kaolin\u2010activated TEG. The TEG\u2010PM variables included MA following the addition of platelet agonists arachidonic acid (MA<jats:sub>AA<\/jats:sub>) and adenosine diphosphate (MA<jats:sub>ADP<\/jats:sub>), and MA due to fibrin alone (MA<jats:sub>Fibrin<\/jats:sub>). In addition, platelet indices and fibrinogen concentrations were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen dogs with complicated <jats:italic>B\u00a0rossi<\/jats:italic> infection and five healthy controls were included. The median MA<jats:sub>Fibrin <\/jats:sub>and fibrinogen concentrations were significantly higher (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.01 for both) and median platelet count was significantly lower (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.01) in the babesiosis group vs the control group. No significant differences were found for MA<jats:sub>Thrombin <\/jats:sub>and MA<jats:sub>AA\/ADP<\/jats:sub>. maximum amplitude due to fibrin alone was positively correlated with fibrinogen concentration (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.735), mean platelet volume (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.517), and mean platelet mass (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.498), and negatively correlated with hematocrit (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.685), platelet count (<jats:italic>r\u00a0<\/jats:italic>=\u00a0\u22120.476), and plateletcrit (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.479) (<jats:italic>P\u00a0&lt;\u00a0<\/jats:italic>0<jats:italic>.<\/jats:italic>05 for all).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study suggests that the presence of hyperfibrinogenemia offsets the severe thrombocytopenia associated with <jats:italic>B rossi<\/jats:italic> to result in normal thromboelastograms and lack of overt clinical bleeding.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vcp.12689","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T11:52:06Z","timestamp":1553860326000},"page":"11-18","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Thromboelastographic platelet mapping in dogs with complicated <i>Babesia rossi <\/i>infection"],"prefix":"10.1111","volume":"48","author":[{"given":"Liesl J.","family":"van Rooyen","sequence":"first","affiliation":[{"name":"Department of Companion Animal Clinical Studies, Faculty of Veterinary Science University of Pretoria Pretoria South Africa"},{"name":"IDEXX Laboratories (Pty) Ltd. 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