{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T20:06:12Z","timestamp":1749672372989},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 10\u2010year\u2010old golden retriever bitch was treated for diarrhea and vomiting that lasted about 1\u00a0month without a specific diagnosis until a hepatic biopsy provided a histopathologic diagnosis of lymphoma. The dog was referred to the Swedish University of Agricultural Science and treated with one dose of <jats:sc>l<\/jats:sc>\u2010asparaginase. The day after chemotherapy, the urine was dark yellow, very turbid, and had large amounts of small amorphous crystals and many casts made of similar appearing material identified by infrared spectroscopy to be 100% uric acid dihydrate. Serum uric acid was elevated at 224\u00a0\u03bcmol\/L (<jats:styled-content style=\"fixed-case\">RI<\/jats:styled-content> 0\u201059). The dog's illness became worse after chemotherapy. Lymphoma treatment was not continued, and the dog was euthanized 9\u00a0days after the <jats:sc>l<\/jats:sc>\u2010asparaginase treatment. Among other problems were persistent proteinuria with a urine protein\u2010to\u2010creatinine ratio of 2.3 and severe hypoalbuminemia. Serum protein electrophoresis performed 3\u00a0weeks prior to chemotherapy indicated hyperproteinemia (total protein 78\u00a0g\/L) having a biclonal gammopathy with 35\u00a0g\/L \u03b2\u20102 globulins and 11\u00a0g\/L \u03b3 globulins. Despite prominent cylinduria and crystalluria, the patient did not develop azotemia or isosthenuria.<\/jats:p>","DOI":"10.1111\/vcp.12719","type":"journal-article","created":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T00:43:52Z","timestamp":1557967432000},"page":"425-428","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Massive uric acid crystalluria and cylinduria in a dog after <scp>l<\/scp>\u2010asparaginase treatment for lymphoma"],"prefix":"10.1111","volume":"48","author":[{"given":"Harold","family":"Tvedten","sequence":"first","affiliation":[{"name":"University Animal Hospital Swedish University of Agricultural Sciences Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inger","family":"Lillieh\u00f6\u00f6k","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Swedish University of Agricultural Sciences Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"R\u00f6nnberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Swedish University of Agricultural Sciences Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"Pelander","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Swedish University of Agricultural Sciences Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,15]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/01652176.1999.9694990"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2013.07.001"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2007.00127.x"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.tb01965.x"},{"key":"e_1_2_4_6_1","first-page":"64","article-title":"Tumor lysis syndrome in a dog","volume":"121","author":"Piek CJ","year":"1996","journal-title":"Tijdschr Diergeneeskd"},{"key":"e_1_2_4_7_1","unstructured":"Anonymous.NEVPC Case 15. 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