{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:27:57Z","timestamp":1793042877839,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T00:00:00Z","timestamp":1559865600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Histoplasmosis is one of the most common systemic fungal diseases in cats from the United States. It commonly causes respiratory or disseminated disease and is often associated with one or more cytopenias. Here, we describe 32 cats in which a <jats:italic>Histoplasma<\/jats:italic>\u2010like fungal infection was associated with concurrent hemophagia in at least one sample site, commonly spleen, bone marrow, liver, and\/or lymph node. The degree of hemophagia was characterized as moderate or marked in the majority of cases, and in all cases, there was a predominance of phagocytized mature erythrocytes. A few cases also had macrophages with phagocytized erythroid precursors, platelets, and\/or neutrophils. Complete blood count results were available for 25 cats, and cytopenias were common (20\/25), including solitary anemia (10), anemia and thrombocytopenia (5), solitary neutropenia (2), pancytopenia (2), and anemia and neutropenia (1). Bone marrow samples were only available in a small subset of cases, preventing the further assessment of the causes of the cytopenias. Hemophagocytosis has been previously reported in cats with neoplastic diseases and a cat with calicivirus infection, and likely occurs with other conditions as well, such as hemorrhage or hemolysis. Results of this report suggest that systemic fungal disease is an additional differential to consider when there is hemophagia in a feline cytology sample.<\/jats:p>","DOI":"10.1111\/vcp.12721","type":"journal-article","created":{"date-parts":[[2019,6,8]],"date-time":"2019-06-08T05:23:51Z","timestamp":1559971431000},"page":"250-254","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hemophagocytosis and <i>Histoplasma<\/i>\u2010like fungal infection in 32 cats"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5260-2180","authenticated-orcid":false,"given":"Deanna M. W.","family":"Schaefer","sequence":"first","affiliation":[{"name":"Department of Biomedical and Diagnostic Sciences University of Tennessee Knoxville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa E.","family":"Rizzi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology Oklahoma State University Stillwater Oklahoma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela B.","family":"Royal","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology University of Missouri Columbia Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,7]]},"reference":[{"key":"e_1_2_4_2_1","first-page":"E1","volume":"33","author":"Lin Blache J","year":"2011","journal-title":"Compend Contin Educ Vet"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X12452494"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-013-0352-2"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X12450121"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2206.151682"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-705111"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-01-550657"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005198"},{"key":"e_1_2_4_10_1","first-page":"48","volume-title":"Cowell and Tyler's Diagnostic Cytology and Hematology of the Dog and Cat","author":"Cowell RL","year":"2014"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/2141-9248.141515"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.2005.00717.x"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2009.1.127"},{"key":"e_1_2_4_14_1","first-page":"726","article-title":"Secondary hemophagocytic lymphohistiocytosis in adults: an update on diagnosis and therapy","volume":"10","author":"Kleynberg RL","year":"2012","journal-title":"Clin Adv Hematol Oncol"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00071-07"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.05017-11"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12015"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1996.tb02017.x"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.71.817"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2008.00005.x"}],"container-title":["Veterinary Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vcp.12721","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vcp.12721","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vcp.12721","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T14:28:22Z","timestamp":1694356102000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vcp.12721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/vcp.12721"],"URL":"https:\/\/doi.org\/10.1111\/vcp.12721","archive":["Portico"],"relation":{},"ISSN":["0275-6382","1939-165X"],"issn-type":[{"value":"0275-6382","type":"print"},{"value":"1939-165X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"2018-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}