{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:51:02Z","timestamp":1761648662788},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T00:00:00Z","timestamp":1557100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 9\u2010year\u2010old mixed breed 13\u00a0kg spayed female dog was presented for evaluation of two masses in the right abdominal mammary gland region. Surgery was conducted to excise the masses. A grade I complex mammary gland carcinoma and high grade (grade III) mast cell tumor with an inguinal lymph node metastasis were diagnosed. Forty\u2010seven days after the surgical procedure, the mast cell tumor relapsed, and neoadjuvant treatment with lomustine (81\u00a0mg\/m<jats:sup>2<\/jats:sup>) was prescribed. Thirteen days from initiation of lomustine therapy, the dog was re\u2010presented to the hospital with bloody diarrhea, hematemesis, epistaxis, an elevated rectal temperature, depression, severe dehydration, and marked dyspnea. The CBC showed severe thrombocytopenia and leukopenia. According to the owner, lomustine (45mg per os [PO]) was mistakenly administered daily for 10 consecutive days (total dose, 810\u00a0mg\/m<jats:sup>2<\/jats:sup>). The dog died and a necropsy was performed. The main gross lesions consisted of severe multifocal hemorrhages in multiple organs, especially in the digestive system. Histopathologic evaluation revealed disseminated hemorrhages, as well as marked bone marrow aplasia. This report describes the clinical, hematologic, gross, and histologic findings in a fatal case of lomustine overdose in a dog.<\/jats:p>","DOI":"10.1111\/vcp.12734","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T02:14:40Z","timestamp":1557195280000},"page":"255-258","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hemorrhagic diathesis and bone marrow aplasia secondary to lomustine overdose in a dog"],"prefix":"10.1111","volume":"48","author":[{"given":"Luan C.","family":"Henker","sequence":"first","affiliation":[{"name":"Department of Veterinary Pathology Universidade Federal do Rio Grande do Sul\u2014UFRGS Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina T.","family":"Kemper","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology Universidade Federal do Rio Grande do Sul\u2014UFRGS Porto Alegre 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