{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T09:06:47Z","timestamp":1747300007696},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T00:00:00Z","timestamp":1557100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA016058"],"award-info":[{"award-number":["P30 CA016058"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mammary carcinoma is rare in cattle with only a handful of cases found in the literature, and none have reported an associated hypercalcemia. An 8\u2010year\u2010old Holstein\u2010Friesian heifer was presented to the Purdue University Veterinary Teaching Hospital's Large Animal Hospital with a 3\u2010month history of lethargy. Laboratory abnormalities included ionized hypercalcemia and hypophosphatemia (2.28\u00a0mmol\/L and 1.8\u00a0mg\/dL, respectively). Physical examination revealed a mammary mass that was cytologically described as a suspected mammary carcinoma, which was later confirmed by histologic evaluation. On surgical removal of the mass, calcium initially decreased rapidly, and within a few days was within the RI, further supporting a diagnosis of hypercalcemia of malignancy in a heifer. However, attempts to confirm this using hormone profiles (parathyroid hormone [PTH], parathyroid hormone\u2010related protein [PTHrp], and calcitriol) were inconclusive due to the lack of validated assays and RIs for cattle. Immunohistochemical staining for PTHrP showed scattered cytoplasmic staining among the neoplastic cells, suggesting PTHrP production by these cells.<\/jats:p>","DOI":"10.1111\/vcp.12739","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T02:20:50Z","timestamp":1557195650000},"page":"293-299","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A case of hypercalcemia in a heifer presumably due to mammary carcinoma bovine hypercalcemia of malignancy"],"prefix":"10.1111","volume":"48","author":[{"given":"Mara S.","family":"Varvil","sequence":"first","affiliation":[{"name":"Department of Comparative Pathobiology Purdue University College of Veterinary Medicine West Lafayette Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gillian","family":"Haanen","sequence":"additional","affiliation":[{"name":"Veterinary Clinical Sciences Purdue University College of 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