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Aleukemic or subleukemic leukemia is a particularly rare variation in both humans and dogs, where bone marrow proliferation is either not or only sparsely translated in the peripheral blood. Neutropenia is a prominent feature in cases of human T\u2010cell LGLL but is normally absent in canine CLL. This report describes a case of a dog presented with an almost 3\u2010year history of asymptomatic neutropenia, lymphopenia, and thrombocytopenia (without anemia). A bone marrow examination, the exclusion of infectious diseases, and clonality testing led to the diagnosis of subleukemic LGLL that responded well to therapy (death occurred 2.5\u00a0years later due to an unrelated cause).<\/jats:p>","DOI":"10.1111\/vcp.12809","type":"journal-article","created":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T07:44:54Z","timestamp":1575618294000},"page":"721-724","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Chronic lymphopenia and neutropenia in a dog with large granular lymphocytic leukemia"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9449-4798","authenticated-orcid":false,"given":"Kristina","family":"Museux","sequence":"first","affiliation":[{"name":"Laboratoire IDEXX Saint Denis 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