{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T04:27:37Z","timestamp":1771302457794,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 2\u2010year\u2010old female intact African pygmy hedgehog was presented for diagnostic investigation of a 2\u2010month reduction in appetite, with weight loss and recent vomiting. Clinical examination revealed a large, firm mass originating from the left cranial abdomen. Ultrasound\u2010guided fine\u2010needle aspirates of the mass, liver, and mesenteric lymph nodes revealed a population of pleomorphic round cells, some of which contained variable numbers of round, clear vacuoles, consistent with a diagnosis of lymphoma with Mott cell differentiation. At postmortem examination, there was marked diffuse splenic enlargement, with infiltration by a soft tissue mass. There were multiple coalescing liver masses, kidney pallor, and mesenteric lymph node enlargements. On histologic examination, the spleen, lymph nodes, and masses in the liver were extensively infiltrated by proliferating lymphoid cells that had plasmacytoid and Mott cell differentiation. Cells with Mott cell morphology had an accumulation of periodic acid\u2010Schiff\u2013positive material in cytoplasmic inclusions and were positive for cytoplasmic nucleic acids when stained with methyl green pyronin. In the population of neoplastic lymphoid cells, a majority of cells expressed the transcription factor Pax5, which drives B\u2010cell differentiation, and a minority expressed transcription factor IRF4\/MUM\u20101, which drives plasma cell differentiation, indicating\u00a0B\u2010cell lymphoma with plasmacytoid differentiation.<\/jats:p>","DOI":"10.1111\/vcp.12816","type":"journal-article","created":{"date-parts":[[2019,12,14]],"date-time":"2019-12-14T04:07:40Z","timestamp":1576296460000},"page":"725-729","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Lymphoma with Mott cell differentiation and validation of immunohistochemical lymphoid markers in an African pygmy hedgehog (<i>Atelerix albiventris<\/i>)"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8967-7717","authenticated-orcid":false,"given":"Paola","family":"Cazzini","sequence":"first","affiliation":[{"name":"Easter Bush Pathology Royal (Dick) School of Veterinary Studies and The Roslin Institute The University of Edinburgh Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenna","family":"Richardson","sequence":"additional","affiliation":[{"name":"Hospital for Small Animals, Rabbit and Exotic Animal Practice Royal (Dick) School of Veterinary Studies and The Roslin Institute The University of Edinburgh Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Smith","sequence":"additional","affiliation":[{"name":"Easter Bush Pathology Royal (Dick) School of Veterinary Studies and The Roslin Institute The University of Edinburgh Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Lodzinska","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging Department Hospital for Small Animals Royal (Dick) School of Veterinary Studies and The Roslin Institute The University of Edinburgh Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy L.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Royal (Dick) School of Veterinary Studies and The Roslin Institute The University of Edinburgh Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian W.","family":"Philbey","sequence":"additional","affiliation":[{"name":"Easter Bush Pathology Royal (Dick) School of Veterinary Studies and The Roslin Institute The University of Edinburgh Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,13]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2008.00101.x"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/jcpa.2000.0441"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.7589\/0090-3558-34.4.801"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-141604985-2.50009-8"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12043"},{"key":"e_1_2_4_7_1","first-page":"35","volume-title":"Ioachim's Lymph Node Pathology","author":"Ioachim HL","year":"2009"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12343"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/54.4.667"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/44076"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2006.01809.x"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2008.00067.x"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800169"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.6.2084"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2012.08.002"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.239.11.1477"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/104063871002200326"}],"container-title":["Veterinary Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvcp.12816","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vcp.12816","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vcp.12816","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vcp.12816","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T22:25:23Z","timestamp":1694125523000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vcp.12816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/vcp.12816"],"URL":"https:\/\/doi.org\/10.1111\/vcp.12816","archive":["Portico"],"relation":{},"ISSN":["0275-6382","1939-165X"],"issn-type":[{"value":"0275-6382","type":"print"},{"value":"1939-165X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"2019-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}