{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:51:33Z","timestamp":1786971093924,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T00:00:00Z","timestamp":1588118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 10\u2010year\u2010old intact male Golden Retriever was presented to The Ohio State University Veterinary Medical Center for acute, non\u2010painful facial swelling of the right mandibular region. On physical examination, the right mandibular swelling was found to represent marked lymphadenopathy of the submandibular lymph node. At this time, marked lymphadenopathy of the prescapular and popliteal lymph nodes was also appreciated. The CBC showed a moderate leukocytosis (38.4\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup> cells\/L, reference interval [RI] 4.8\u201013.9\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup> cells\/L) characterized by a moderate lymphocytosis (28.4\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup> cells\/L, RI 1.0\u20104.6\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup> cells\/L). Evaluation of peripheral blood and enlarged prescapular and popliteal lymph nodes revealed two morphologically different populations of homogeneous lymphocytes, with the lymphocyte population in the lymph nodes being distinct from that in the blood smear. Flow cytometry of peripheral blood revealed CD45\u2010, CD5+, CD4\u2010, CD8\u2010, variably CD21+ neoplastic lymphocytes compatible with T\u2010zone lymphocytes due to the absence of CD45 expression. Flow cytometry of the lymph node aspirate indicated a distinct population of CD21+ lymphocytes consistent with a B\u2010cell phenotype along with a smaller proportion of the T\u2010zone lymphocytes observed in the blood confirming the presence of two distinct populations of neoplastic lymphocytes, one involving T cells, and the other involving B cells.<\/jats:p>","DOI":"10.1111\/vcp.12855","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T09:59:30Z","timestamp":1588154370000},"page":"307-311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Lymphocytosis and lymphadenopathy in a dog arising from two distinct lymphoid neoplasms"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6387-4440","authenticated-orcid":false,"given":"Mackenzie E.","family":"Long","sequence":"first","affiliation":[{"name":"Department of Veterinary Biosciences The Ohio State University Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences The Ohio State University Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne C.","family":"Avery","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Biomedical Sciences Colorado State University Fort Collins CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxey L.","family":"Wellman","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biosciences The Ohio State University Columbus OH 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