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The patient was staged using thoracic radiographs, abdominal ultrasound, and fine\u2010needle aspirates of the mandibular lymph nodes and spleen. Given the absence of any definitive evidence of metastasis, the malignant melanoma was surgically completely removed. The dog then received four melanoma vaccine doses as an adjuvant therapy and remained clinically healthy for more than 3\u00a0months after the last immunization. However, 232\u00a0days after the initial discovery of the lip mass, the dog was euthanized due to deterioration and a poor prognosis based on the presence of lung metastases and neoplastic melanocytic pleural effusion. The latter has been rarely reported in dogs, despite the high prevalence of oral malignant melanomas and the tendency of these tumors to metastasize to the lungs.<\/jats:p>","DOI":"10.1111\/vcp.12919","type":"journal-article","created":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T06:40:57Z","timestamp":1607409657000},"page":"652-654","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neoplastic melanocytic pleural effusion in a Portuguese water dog"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8032-0327","authenticated-orcid":false,"given":"Erica","family":"Corda","sequence":"first","affiliation":[{"name":"Department of Pathobiology and Diagnostic Investigation College of Veterinary Medicine Michigan State University East Lansing MI USA"},{"name":"Michigan State University Veterinary Diagnostic Laboratory College of Veterinary Medicine Michigan State University East Lansing MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8381-180X","authenticated-orcid":false,"given":"Paulo","family":"Vilar Saavedra","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences College of Veterinary Medicine Michigan State University East Lansing MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2561-0588","authenticated-orcid":false,"given":"Nora","family":"Berghoff","sequence":"additional","affiliation":[{"name":"Department of Pathobiology and Diagnostic Investigation College of Veterinary Medicine Michigan State University East Lansing MI USA"},{"name":"Michigan State University Veterinary Diagnostic Laboratory College of Veterinary Medicine Michigan State University East Lansing MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca C.","family":"Smedley","sequence":"additional","affiliation":[{"name":"Department of Pathobiology and Diagnostic Investigation College of Veterinary Medicine Michigan State University East Lansing MI USA"},{"name":"Michigan State University Veterinary Diagnostic Laboratory College of Veterinary Medicine Michigan State University East Lansing MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer S.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Pathobiology and Diagnostic Investigation College of Veterinary Medicine Michigan State University East Lansing MI USA"},{"name":"Michigan State University Veterinary Diagnostic Laboratory College of Veterinary Medicine Michigan State University East Lansing MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,7]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.39-6-651"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2003.tb00468.x"},{"key":"e_1_2_4_4_1","first-page":"485","article-title":"In die Brusth\u00f6hle metastasierendes malignes Melanom mit Pleuraergu\u00df bei einem Hund. 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