{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T15:01:32Z","timestamp":1771340492547,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T00:00:00Z","timestamp":1614643200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 12\u2010year\u2010old spayed female Shiba Inu dog was referred to our hospital for a suspected mast cell tumor (MCT) of the bone marrow (BM). Laboratory abnormalities included severe nonregenerative anemia (packed cell volume or PCV: 12.5%; reference interval (RI): 37.3\u201061.7%; reticulocytes: 35.1\u00a0\u00d7\u00a010<jats:sup>3<\/jats:sup>\/\u00b5L; RI: 10\u2010110\u00a0\u00d7\u00a010<jats:sup>3<\/jats:sup>\/\u00b5L), and a few mast cells were visualized in the blood smear examination. The BM was hypercellular with hematopoietic cells, a decreased myeloid:erythroid (M:E) ratio (0.77; RI, 0.9\u20101.8), and no dysplastic hematopoietic cells. Mast cells accounted for 11.5% of the total nucleated BM cells. Neoplastic mast cells and histiocytes phagocytizing erythroid progenitor cells were occasionally noted. The dog was diagnosed with precursor\u2010targeted immune\u2010mediated anemia (PIMA) concurrent and a stage IV MCT infiltrating the BM. Multimodal treatment included toceranib, imatinib, vinblastine, lomustine (CCNU), prednisolone, cyclosporine, mycophenolate mofetil, and a blood transfusion. The dog died due to MCT progression lasting 139\u00a0days after the initial BM examination. To the best of our knowledge, this is the first report of a dog presenting with PIMA and a stage IV MCT infiltrating the BM.<\/jats:p>","DOI":"10.1111\/vcp.12982","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T02:23:06Z","timestamp":1614738186000},"page":"151-157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Precursor\u2010targeted immune\u2010mediated anemia in a dog with a stage IV mast cell tumor and bone marrow infiltration"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2875-2066","authenticated-orcid":false,"given":"Makoto","family":"Akiyoshi","sequence":"first","affiliation":[{"name":"Laboratory of Small Animal Internal Medicine School of Veterinary Medicine Azabu University Sagamihara City Japan"},{"name":"Akiyoshi Animal Clinic Yamato City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3738-6659","authenticated-orcid":false,"given":"Masaharu","family":"Hisasue","sequence":"additional","affiliation":[{"name":"Laboratory of Small Animal Internal Medicine School of Veterinary Medicine Azabu University Sagamihara City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakurako","family":"Neo","sequence":"additional","affiliation":[{"name":"Laboratory of Small Animal Internal Medicine School of Veterinary Medicine Azabu University Sagamihara City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masami","family":"Akiyoshi","sequence":"additional","affiliation":[{"name":"Akiyoshi Animal Clinic Yamato City 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